Synthesis, characterization and bioactivities of dative donor ligand N-heterocyclic carbene (NHC) precursors and their Ag(I)NHC coordination compounds

Kazancı, Ali; Gök, Yetkın; Kaya, Rüya; Aktaş, Aydın; Taslimi, Parham; Gülçın, İlhami

doi:10.1016/j.poly.2020.114866

Cited by 42 publications

(39 citation statements)

References 105 publications

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“…Ethanol extract of kınkor ( Ferulago stell ata ) had IC 50 values of 0.826 μg/mL (r 2 : 0.9491) toward α-glycosidase and 0.639 μg/mL against α-amylase enzyme (r 2 : 0.9580). The results show that ethanol extract of kınkor ( Ferulago stell ata ) as a crude extract exhibited efficient α-glycosidase and α-amylase inhibition effect when compared to acarbose as a starch blocker, which had IC 50 of 10.00 μM for α-amylase and 22.80 μM for α-glycosidase [ 63 ].…”

Section: Resultsmentioning

confidence: 99%

LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)

et al. 2021

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Kınkor (Ferulago stellata) is Turkish medicinal plant species and used in folk medicine against some diseases. As far as we know, the data are not available on the biological activities and chemical composition of this medicinal plant. In this study, the phytochemical composition; some metabolic enzyme inhibition; and antidiabetic, anticholinergic, and antioxidant activities of this plant were assessed. In order to evaluate the antioxidant activity of evaporated ethanolic extract (EEFS) and lyophilized water extract (WEFS) of kınkor (Ferulago stellata), some putative antioxidant methods such as DPPH· scavenging activity, ABTS•+ scavenging activity, ferric ions (Fe3+) reduction method, cupric ions (Cu2+) reducing capacity, and ferrous ions (Fe2+)-binding activities were separately performed. Furthermore, ascorbic acid, BHT, and α-tocopherol were used as the standard compounds. Additionally, the main phenolic compounds that are responsible for antioxidant abilities of ethanol and water extracts of kınkor (Ferulago stellata) were determined by liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Ethanol and water extracts of kınkor (Ferulago stellata) demonstrated effective antioxidant abilities when compared to standards. Moreover, ethanol extract of kınkor (Ferulago stellata) demonstrated IC50 values of 1.772 μg/mL against acetylcholinesterase (AChE), 33.56 ± 2.96 μg/mL against α-glycosidase, and 0.639 μg/mL against α-amylase enzyme respectively.

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Section: Resultsmentioning

confidence: 99%

LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)

et al. 2021

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“…All the synthesized Ag(I)NHC complexes ( 1a–e and 2a–e ) were shown in Schemes 1 and 2, and they are all synthesized according to the literature. [ 40–42,56 ] The structures of all complexes were characterized by NMR ( 1 H NMR and 13 C NMR), FT‐IR spectroscopy, and elemental analysis techniques. The new Ag(I)NHC complexes ( 1a–e and 2a–e ) were synthesized from the starting material benzimidazolium salts [ 55 ] and silver oxide via in situ deprotonation method.…”

Section: Resultsmentioning

confidence: 99%

“…[ 30,31 ] NHC ligands in many Ag(I)NHC complexes contain diverse and versatile functionalized groups. This property makes them more effective as antibacterial, [ 32 ] antimicrobial, [ 33 ] anticancer, [ 24,34,35 ] antioxidant, [ 36 ] antihemolytic, [ 36 ] antitumor, [ 37 ] DNA interaction, [ 38 ] enzyme inhibitors, [ 39–42 ] and chemotherapeutic agents. [ 43 ] Hence, these Ag(I)NHC complexes are worth to be examined as medicinal drugs.…”

Section: Introductionmentioning

confidence: 99%

“…Few studies have been published using Ag(I)NHC complexes as enzyme inhibitors. [ 39–42 ] We recently published a study on the enzyme inhibition activities of new Ag(I)NHC complexes. Herein, we synthesized two new series of Ag(I)NHC complexes.…”

Section: Introductionmentioning

confidence: 99%

“…Herein, we synthesized two new series of Ag(I)NHC complexes. [ 40–42 ] We have fully characterized the structures of all complexes by spectroscopic analysis techniques. Furthermore, we investigated their inhibitory effects on some metabolic enzymes.…”

Section: Introductionmentioning

confidence: 99%

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Silver N‐heterocyclic carbene complexes bearing fluorinated benzyl group: Synthesis, characterization, crystal structure, computational studies, and inhibitory properties against some metabolic enzymes

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Demirci

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Applied Organom Chemis

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A series of the silver N‐heterocyclic carbene (NHC) complexes have been synthesized from the reactions between benzimidazolium salts bearing fluorinated benzyl group and Ag2O via the deprotonation method. All Ag(I)NHC complexes were characterized by known spectroscopic techniques (1H nuclear magnetic resonance [NMR], 13C NMR, and Fourier transform infrared [FT‐IR]) and elemental analysis. The molecular structures of the two complexes were unambiguously elucidated through single‐crystal X‐ray diffraction analysis. Namely, X‐ray studies show that the coordination geometry around the Ag(I) atom in the case of complex 2c is revealed to be almost linear with C–Ag–Cl angle, whereas in complex 2e, it appears as a nonlinear structure. The inhibitory profiles of these new complexes are investigated on some metabolic enzymes. Representatively, the most potent complex against human carbonic anhydrase isoenzymes I and II (hCAs I and II), 2d, was 1.8 times more potent than standard inhibitor acetazolamide against hCAs I and II. On the other hand, complexes 2c and 2b as most potent compounds against both cholinesterase enzymes was around 5 and 1.6 times more potent than tacrine against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. The most active α‐glucosidase inhibitor 2d had similar activity to acarbose as a standard inhibitor. Furthermore, it confirms its in vitro studies as a result of molecular docking studies for each enzyme with (i) binding energy and inhibition constant values and (ii) the definition of the best conformation and nonbonding interactions of the related complexes (2b, 2c, and 2d) against the different target proteins.

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Chemistry of heterocycles as carbonic anhydrase inhibitors: A pathway to novel research in medicinal chemistry review

Bendi,

Taruna,

Rajni

et al. 2024

Archiv der Pharmazie

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Nowadays, the scientific community has focused on dealing with different kinds of diseases by exploring the chemistry of various heterocycles as novel drugs. In this connection, medicinal chemists identified carbonic anhydrases (CA) as one of the biologically active targets for curing various diseases. The widespread distribution of these enzymes and the high degree of homology shared by the different isoforms offer substantial challenges to discovering potential drugs. Medicinal and synthetic organic chemists have been continuously involved in developing CA inhibitors. This review explored the chemistry of different heterocycles as CA inhibitors using the last 11 years of published research work. It provides a pathway for young researchers to further explore the chemistry of a variety of synthetic as well as natural heterocycles as CA inhibitors.

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Synthesis, characterization and bioactivities of dative donor ligand N-heterocyclic carbene (NHC) precursors and their Ag(I)NHC coordination compounds

Cited by 42 publications

References 105 publications

LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)

LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)

Silver N‐heterocyclic carbene complexes bearing fluorinated benzyl group: Synthesis, characterization, crystal structure, computational studies, and inhibitory properties against some metabolic enzymes

Chemistry of heterocycles as carbonic anhydrase inhibitors: A pathway to novel research in medicinal chemistry review

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