Synthesis, Characterization and Antitumor Activity ofcis‐bis(acylthioureato) platinum(II) Complexes, cis‐[PtL2] [HL1=N,N‐Diphenyl‐N′‐Benzoylthiourea or HL2=N,N‐diphenyl‐N′‐(p‐nitrobenzoyl)thiourea]

Abstract

A low-molecular weight chromium-containing fraction of the material resulting from dichromate reduction by bovine liver homogenate was investigated by NMR and ES-MS. The ES-MS spectrum showed a readily detectable peak at m/z 786.1. The same molecular weight reasonably agreed with the relatively low diffusion coefficient measured by NMR-DOSY experiments on the main species observed in the 1H NMR spectrum. At least two downfield shifted and broad paramagnetic signals were apparent in the 1H NMR spectrum. Temperature dependence of chemical shift was exploited in order to estimate the diamagnetic shift of the signals in the diamagnetic region of the spectrum. 2D TOCSY, NOESY, COSY and 1H-13C HMQC spectra revealed the presence of aromatic protons (which were assigned as His residues), Gly and some other short chain amino-acids. Combinations of the molecular masses of such components together with acetate (which is present in the solution) and chromium atoms allowed a tentative proposal of a model for the compound.

Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium (II) and Platinum (II) Complexes against Various Human Tumor Cell Lines

“…As shown in Table 4, the palladium (II) and platinum (II) complexes were more cytotoxic (IC 50 = 0.08–12.46 μ M) than their respective ligands. These results reveal that the cytotoxic activity increases dramatically when ligands are coordinated to the metal ion [18, 19, 32]. …”

Ru(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands: Synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells

“…The free ligands present an intense band in the region between 1800 and 1610 cm -1 , which is assigned to vC=O stretching vibrations [28,29,55] and is absent in the spectra of the complexes, evidencing …”

“…The complexes exhibit νRu-P stretching in the range 521-511 cm -1 . Also, the νRu-S, νRu-N and νRu-O stretching vibrations occur as weak bands in a region of low intensity at about 500-350 cm -1 [55].3.4 Multinuclear 31 P{ 1 H}, 1 H and 13 C NMR experimentsIn the 1 H NMR spectra of the free ligands, a shoulder band corresponding to a singlet of the N-H group proton is observed in the region of 8.10-8.70 ppm[28,29,50]. This kind of signal is absent in the spectra of the complexes, indicating the deprotonation of the acylthioureide group by the coordination of the ligand, which acts as a monoanionic species, to the metal.…”

Synthesis, characterization and antibacterial activity of nickel (II) and copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide

“…It has been reported that substituted acylthiourea ligands might act as monodentate sulfur donors, bidentate oxygen and nitrogen donors. They could also coordinate through the keto-or enolthione form, depending of the ligands themselves, and the metal ions and counter-anions used [18][19][20][21][22][23].…”