Synthesis, characterization, and antimicrobial activity of some thiazole derivatives

Al-Mathkuri, Tahseen Saddam Fandi; Sabti, Asmaa B.; Raheem, A. A. Abd El

doi:10.21608/ejchem.2021.102830.4766

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“…Nitrogen-containing heterocycles are of great importance to both medicinal and organic chemists, and the design and synthesis of these compounds continue to represent a challenge from both an academic and industrial perspective [10]. Many of these compounds have attracted considerable attention due to the wide spectrum of their pharmacological activities such as antiinflammatory [11], antimicrobial [12][13][14][15], antioxidant [16], anticancer [17], antihypertensive [18], antiviral [19], diuretic [20], anti-HIV [21], anticonvulsant [22], and anti-tubercular agents [23]. Accordingly, we report herein about methods for the synthesis and modification of such ring systems and evaluation of the new synthesized heterocyclic systems as antioxidant and antimicrobial agents.…”

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confidence: 99%

Heterocyclization of Thiourea Derivative to Novel Azines and Azoles: Antioxidant and Antimicrobial studies

et al. 2022

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N,N'-disubstituted thiourea derivative 2 underwent oxidative cyclization with Br2/AcOH mixture to give thiazole 3.Thiadiazole 6 was obtained as the result of chlorination of 2 followed by amination and subsequent intramolecular cyclodehydraration. Thermal treatment of N,N'-disubstituted thiourea derivative 2 with TEA in DMF resulted in hydrolysis of 2 to furnish thiourea derivative 8. Treatment of compound 8 with semicarbazide, thiosemicarbazide, diethyl succinate, diethyl malonate / benzaldehyde or urea resulted in the formation of triazoles 11a,b, pyrrole 13, thiazine 16 and oxathiazole 19. The newly synthesized compounds were tested for their antioxidant and antimicrobial activities.

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