Synthesis Characterization and Antimicrobial Activities of Azithromycin Metal Complexes

Sultana, Najma

doi:10.4172/2329-6798.1000133

Cited by 9 publications

(3 citation statements)

References 16 publications

(20 reference statements)

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“…The oxazolidin ring of linezolid and its peptide bond may chelate with zinc/calcium. Furthermore, vancomycin [91], bacitracin [92,93], isoniazid [89], macrolides [94][95][96], ß-lactams [97][98][99][100][101][102][103][104][105][106][107], nitroxoline [108,109], and chloramphenicol [110] formed chelates or complexes with zinc and calcium, whereas streptomycin did not [89].…”

Section: Antibiotics Inhibit Metallo-matrix-proteinasesmentioning

confidence: 99%

“…Mitochondrial dysfunction (S109, S110) Tetracyclines [87][88][89][311][312][313][314] Macrolides [94][95][96] Vancomycin [91] ß-lactams [97][98][99][100][101][102][103][104][105][106][107] Bacitracin [92,93] Isoniazid [89] Nitroxoline [108,109] Inhibition of MMP activity and/or reduction of gene expression in vitro Oxazolidinones (S128, S129) Tetracyclines (S111, S130-S187) Macrolides (S114-S127) Vancomycin (91, S198) ß-lactams (S111-S113) Bacitracin (S199) Isoniazid (S122, S195) Nitroxoline (S200, S201)…”

Section: S110)mentioning

confidence: 99%

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Selective toxicity of antibacterial agents—still a valid concept or do we miss chances and ignore risks?

Dalhoff

2020

Infection

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Background Selective toxicity antibacteribiotics is considered to be due to interactions with targets either being unique to bacteria or being characterized by a dichotomy between pro- and eukaryotic pathways with high affinities of agents to bacterial- rather than eukaryotic targets. However, the theory of selective toxicity oversimplifies the complex modes of action of antibiotics in pro- and eukaryotes. Methods and objective This review summarizes data describing multiple modes of action of antibiotics in eukaryotes. Results Aminoglycosides, macrolides, oxazolidinones, chloramphenicol, clindamycin, tetracyclines, glycylcyclines, fluoroquinolones, rifampicin, bedaquillin, ß-lactams inhibited mitochondrial translation either due to binding to mitosomes, inhibition of mitochondrial RNA-polymerase-, topoisomerase 2ß-, ATP-synthesis, transporter activities. Oxazolidinones, tetracyclines, vancomycin, ß-lactams, bacitracin, isoniazid, nitroxoline inhibited matrix-metalloproteinases (MMP) due to chelation with zinc and calcium, whereas fluoroquinols fluoroquinolones and chloramphenicol chelated with these cations, too, but increased MMP activities. MMP-inhibition supported clinical efficacies of ß-lactams and daptomycin in skin-infections, and of macrolides, tetracyclines in respiratory-diseases. Chelation may have contributed to neuroprotection by ß-lactams and fluoroquinolones. Aminoglycosides, macrolides, chloramphenicol, oxazolidins oxazolidinones, tetracyclines caused read-through of premature stop codons. Several additional targets for antibiotics in human cells have been identified like interaction of fluoroquinolones with DNA damage repair in eukaryotes, or inhibition of mucin overproduction by oxazolidinones. Conclusion The effects of antibiotics on eukaryotes are due to identical mechanisms as their antibacterial activities because of structural and functional homologies of pro- and eukaryotic targets, so that the effects of antibiotics on mammals are integral parts of their overall mechanisms of action.

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Section: Antibiotics Inhibit Metallo-matrix-proteinasesmentioning

confidence: 99%

Section: S110)mentioning

confidence: 99%

Selective toxicity of antibacterial agents—still a valid concept or do we miss chances and ignore risks?

Dalhoff

2020

Infection

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“…[ 39 ] It has been demonstrated that Azi can form complexes with metal ions and be used as an efficient and safe antifungal drug. [ 40 ] Meanwhile, Azi can serve as a metal corrosion inhibitor due to its presence of heteroatoms and unsaturated bonds, forming a protective layer on metal surface. [ 41 ] Therefore, exploiting Zn ionophores as additives is expected to collectively address the mentioned challenges of Zn batteries.…”

Section: Introductionmentioning

confidence: 99%

Zn Ionophores to Suppress Hydrogen Evolution and Promote Uniform Zn Deposition in Aqueous Zn Batteries

Bai,

Nan,

Yang

et al. 2023

Adv Funct Materials

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Uncontrolled Zn dendrites and undesirable side reactions such as Zn self‐corrosion and hydrogen evolution reaction (HER) remain major challenges for the further development of aqueous Zn batteries (AZBs). In this study, macrolide antibiotics are proposed to be added to aqueous electrolyte, serving as Zn ionophores to modulate Zn2+ solvation structure, regulate Zn electrodeposition, and suppress undesirable parasitic reactions. Azithromycin (Azi), a representative macrolide antibiotic, is demonstrated to undergo bidentate coordination with Zn ions and remodel the solvation structure into [ZnAzi(H2O)4]2+. Meanwhile, the self‐corrosion and HER at the Zn anode side are significantly suppressed, evidenced quantitatively by the on‐line hydrogen production monitoring. Furthermore, the promotion of dense and uniform Zn electrodeposition by the ionophores is also confirmed. The repeated Zn plating/stripping test with 0.1 m Azi in electrolyte reaches a high cumulative capacity of 10 Ah cm−2 at a current density of 10 mA cm−2 and an area capacity of 10 mAh cm−2. Moreover, the corresponding Zn‐V2O5 pouch cell achieves stable operation for 100 cycles without bulging caused by gas evolution. Thus, the electrolyte engineering approach presents a practically viable strategy for the development of AZBs.

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Imipenem-metal complexes: Computational analysis and toxicity studies with wastewater model microorganisms

Khurana,

Pulicharla,

Brar

2023

Environmental Research

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Synthesis Characterization and Antimicrobial Activities of Azithromycin Metal Complexes

Cited by 9 publications

References 16 publications

Selective toxicity of antibacterial agents—still a valid concept or do we miss chances and ignore risks?

Selective toxicity of antibacterial agents—still a valid concept or do we miss chances and ignore risks?

Zn Ionophores to Suppress Hydrogen Evolution and Promote Uniform Zn Deposition in Aqueous Zn Batteries

Imipenem-metal complexes: Computational analysis and toxicity studies with wastewater model microorganisms

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