Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents

Pantoprazole Derivatives: Synthesis, Urease Inhibition Assay and In Silico Molecular Modeling Studies

“…In this context, 1,3,4‐oxadiazole derivatives are one of the most important heterocyclic compounds that have received considerable attention over the past years. Compounds containing this nucleus have diverse pharmacological properties such as antifungal, antioxidant, antibacterial, antitubercular and anticonvulsant . Moreover, 1,3,4‐oxadiazoles are well known as efficient amide and/or ester bioisosteres which enhance the biological responses by participating in hydrogen bonding interactions with different receptors…”

Novel Polyfunctional Pyridines as Anticancer and Antioxidant Agents. Synthesis, Biological Evaluation and <i>in Silico</i> ADME-T Study

“…15) Moreover, ROS are known to provoke tumor growth and metastasis through induction of angiogenesis, 16) therefore, antioxidants capable of scavenging free radicals proved to contribute efficiently in the treatment of many types of cancer. 17) As far as the chemotherapeutic potential is concerned, pyridine derivatives have come into view as heterocycles with versatile antimicrobial, 18) antitubercular 19) and anticancer [20][21][22] activities. Most notably, several functionalized pyridinecarbonitriles have received much interest for their peculiar antineoplastic [23][24][25] as well as antioxidant 26,27) activities.…”

Preparation, biological evaluation and molecular docking study of imidazolyl dihydropyrimidines as potential Mycobacterium tuberculosis dihydrofolate reductase inhibitors

“…33 Additionally, PA-824, a nitroimidazopyran displayed potent in vitro activity against Mtb, a narrow spectrum of activity limited primarily to the Mtb complex with no noticeable cross-resistance to a wide range of antituberculosis drugs. 34 Keeping all these facts in mind and in continuation of our previous endeavor, [35][36][37][38][39][40][41][42] it was envisaged to design, synthesize and investigate in vitro efficacy of new prototypes including the advantage of dual pharmacophore of dihydropyrimidine and imidazole in a single molecular platform. Furthermore, molecular docking studies of most active compounds against the active site of the Mtb DHFR enzyme helped in revealing the potential mode of action through their interactions.…”