Synthesis, antimalarial and antitubercular activities of meridianin derivatives

Yadav, Rammohan R.; Khan, Shabana I.; Singh, Samsher; Khan, Inshad Ali; Vishwakarma, Ram A.; Bharate, Sandip B.

doi:10.1016/j.ejmech.2015.05.020

Cited by 51 publications

(36 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[56,57] Thus, indole hybrids are a useful platform for the nitro group was beneficial for the activity. [58] Two hybrids 16a,b (IC 50 :…”

Section: Indole Hybridsmentioning

confidence: 99%

The antimalarial activity of indole alkaloids and hybrids

Sun

et al. 2020

Archiv der Pharmazie

View full text Add to dashboard Cite

Malaria, caused by the genus Plasmodium, remains a global public health concern. It is estimated by the World Health Organization that over 40% of the world's population lives in areas at risk for malarial transmission, and around half a million people succumb to this infectious disease annually, which is related to the rapid spread of drug-resistant parasite strains. Indole derivatives, which possess broadspectrum pharmacological properties, play a crucial role in the discovery of new drugs. Many indole derivatives exhibited potential in vitro and in vivo activity against both drug-sensitive and drug-resistant malaria, suggesting that the indole moiety is a useful template for the development of novel antimalarial agents.

show abstract

“…[56,57] Thus, indole hybrids are a useful platform for the nitro group was beneficial for the activity. [58] Two hybrids 16a,b (IC 50 :…”

Section: Indole Hybridsmentioning

confidence: 99%

The antimalarial activity of indole alkaloids and hybrids

Sun

et al. 2020

Archiv der Pharmazie

View full text Add to dashboard Cite

show abstract

“…In medical science, indole based therapeutic drugs possess valuable biologic activities such as anti-HIV (Human immunodeficiency virus), antimicrobial, anti-malarial, antiviral, anti-fungal, antileishmanial, anti-oxidant, and anti-tubercular Fig. 1B [26][27][28][29][30][31][32][33] . Indole is a principal structural molecule which is explained as a privileged scaffold.…”

Section: Fig 1: (A) Discovery Of Indole (B) Pharmacological Profilementioning

confidence: 99%

Untitled

2020

IJPSR

View full text Add to dashboard Cite

“…Especially, compounds, d11 and d12 displayed promising antiplasmodial activity and comparable to the standard drugs (Table 36 , Fig. 9 ) [ 47 ].…”

Section: Biological Significance Of Pyrimidine Scaffoldsmentioning

confidence: 99%

Therapeutic potential of heterocyclic pyrimidine scaffolds

Kumar

2018

Chemistry Central Journal

149

View full text Add to dashboard Cite

Heterocyclic compounds offer a high degree of structural diversity and have proven to be broadly and economically useful as therapeutic agents. Comprehensive research on diverse therapeutic potentials of heterocycles compounds has confirmed their immense significance in the pathophysiology of diseases. Heterocyclic pyrimidine nucleus, which is an essential base component of the genetic material of deoxyribonucleic acid, demonstrated various biological activities. The present review article aims to review the work reported on therapeutic potentials of pyrimidine scaffolds which are valuable for medical applications during new generation.

show abstract

Synthesis, antimalarial and antitubercular activities of meridianin derivatives

Cited by 51 publications

References 22 publications

The antimalarial activity of indole alkaloids and hybrids

The antimalarial activity of indole alkaloids and hybrids

Untitled

Therapeutic potential of heterocyclic pyrimidine scaffolds

Contact Info

Product

Resources

About