Synthesis and Thermally Reversible Assembly of DNA−Gold Nanoparticle Cluster Conjugates

Kim, Ji-Young; Lee, Jae Seung

doi:10.1021/nl9030709

Cited by 89 publications

(72 citation statements)

References 56 publications

(113 reference statements)

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“…Metallic nanoparticles (NPs) have been shown to exhibit defined color changes between individual nanoparticles and aggregated clusters [37,38]. This characteristic has been used in colorimetric assays based on DNAfunctionalized gold nanoparticles (AuNPs) that provide an optical readout (visual color change) (Figure 2(c), top).…”

Section: Nanoparticle-basedmentioning

confidence: 99%

DNA Nanobiosensors: An Outlook on Signal Readout Strategies

Chandrasekaran¹

2017

Journal of Nanomaterials

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A suite of functionalities and structural versatility makes DNA an apt material for biosensing applications. DNA-based biosensors are cost-effective and sensitive and have the potential to be used as point-of-care diagnostic tools. Along with robustness and biocompatibility, these sensors also provide multiple readout strategies. Depending on the functionality of DNA-based biosensors, a variety of output strategies have been reported: fluorescence-and FRET-based readout, nanoparticle-based colorimetry, spectroscopy-based techniques, electrochemical signaling, gel electrophoresis, and atomic force microscopy.

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Section: Nanoparticle-basedmentioning

confidence: 99%

DNA Nanobiosensors: An Outlook on Signal Readout Strategies

Chandrasekaran¹

2017

Journal of Nanomaterials

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“…The solution was kept at room temperature for 30 min to destroy the formate esters formed in the reaction, after which it was poured into ice water (1.5 l). The precipitate was collected and Soxhlet extracted with methanol for 20 h. After rigorous drying, per-6-iodo-β-cyclodextrin was recovered as a white powder in 50% yield: MS m/z (positive ion ESI) 1903 for [M+Na] + , 1 H NMR (600 MHz, DMSO-d 6 δ) 3.24-3.68 (m, H-2, H-3, H-4, H-5, H-6a), 3.79 (bd, J = 9 Hz, 7 H, H-6b), 4.97 (d, J = 3 Hz, 7 H, H-1), 5.91 (7 H, OH-3), 6.02 (d, J = 5.4 Hz, 7 H, OH-2).…”

Section: Synthesis Of Per-6-iodo-β-cyclodextrinmentioning

confidence: 99%

Vesicular gold assemblies based on host–guest inclusion and its controllable release of doxorubicin

Kang

Peng

et al. 2013

Nanotechnology

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We have developed a kind of gold nanoparticle (AuNP) in which polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAM) are attached on the surface of a gold nanocrystal through the host-guest inclusion between adamantane groups (ADA) and β-cyclodextrin (β-CD). The resulting AuNPs become amphiphilic in water above body temperature and self-assemble into vesicles. It is found that these vesicles can load doxorubicin (Dox) effectively. With a decrease in temperature, the PNIPAM shifted from hydrophobic to hydrophilic, causing Au vesicles to disassemble into stable small AuNPs, triggering the release of Dox. These hybrid vesicles, combining polymer functionality with the intriguing properties of AuNPs, can first release free Dox and AuNP/Dox at a site of a tumor through the application of either simple ice packs or deeply penetrating cryoprobes, then the AuNP/Dox can be taken in by tumor cells and destroy them like miniature munitions. Furthermore, these vesicles showed other therapeutic possibilities due to the presence of gold. We believe that the development of such multi-functional vesicles will provide new and therapeutically useful means for medical applications.

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“…Other DNA detection schemes have been reported, for example, one which is used as a capture oligonucleotide combined with a DNA probe attached to a gold nanoparticle. 47 This method can detect a single mismatch measured by resonance. Wu et al 48 reported the effect of different phosphate buffer concentrations suggesting that electrostatic repulsive forces between neighboring DNA molecules must play a role in cantilever motion and demonstrating that configurational entropy changes and the intermolecular interactions can control the direction of motion in nanomechanical sensors.…”

Section: State-of-the-artmentioning

confidence: 99%

Biomedical applications of nanobiosensors: the state-of-the-art

Rai¹,

Gade²,

Gaikwad³

et al. 2012

J. Braz. Chem. Soc.

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O desenvolvimento de nanobiosensores é um dos avanços mais recentes no campo da nanotecnologia. A investigação sobre nanobiosensores ópticos com dimensões submicrométricas tem aberto novos horizontes para as medições intracelulares. Aproveitando as propriedades únicas dos nanomateriais, nanobiosensores mais rápidos e sensíveis podem ser desenvolvidos. Além de serem sensíveis e rápidos, os estudos de nanobiosensores têm voltado seus esforços para o desenvolvimento de sensores baseados em nanomateriais que são acessíveis, robustos e reprodutíveis. Os nanobiosensores estão equipados com sondas biorreceptoras imobilizadas, por exemplo, anticorpos, substrato de enzima. A excitação por laser é transmitida para o sistema fotométrico na forma de sinal óptico (fluorescência). Os nanobiosessores poderão revolucionar no futuro o diagnóstico de doenças. A presente revisão discute os conceitos básicos, a evolução e as aplicações biomédicas de nanobiosensores.Development of nanobiosensor is one of the most recent advancement in the field of Nanotechnology. Research on optical nanobiosensors with submicron-sized dimensions has opened new horizons for intracellular measurements. Taking advantage of the unique properties of the nanomaterials, faster and sensitive nanobiosensors can be developed. Apart from being sensitive and fast, the studies related to nanobiosensors have geared their efforts towards the development of nanomaterial-based sensors that are affordable, robust and reproducible. The nanobiosensors are equipped with immobilized bioreceptor probes, e.g., antibodies, enzyme substrate. Laser excitation is transmitted to photometric system in the form of optical signal (fluorescence). Nanobiosensors will revolutionize the future of disease diagnosis. The present review discusses the basic concepts, developments and the biomedical applications of nanobiosensors.

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Synthesis and Thermally Reversible Assembly of DNA−Gold Nanoparticle Cluster Conjugates

Cited by 89 publications

References 56 publications

DNA Nanobiosensors: An Outlook on Signal Readout Strategies

DNA Nanobiosensors: An Outlook on Signal Readout Strategies

Vesicular gold assemblies based on host–guest inclusion and its controllable release of doxorubicin

Biomedical applications of nanobiosensors: the state-of-the-art

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