DOI: 10.1016/j.bmc.2010.09.060
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Abstract: A series of benzyl esters of meperidine and normeperidine were synthesized and evaluated for binding affinity at serotonin, dopamine and norepinephrine transporters. The 4-methoxybenzyl ester 8b and 4-nitrobenzyl ester 8c in the meperidine series and 4-methoxybenzyl ester 14a in the normeperidine series exhibited low nanomolar binding affinities at the SERT (Ki values < 2 nM) and high SERT selectivity (DAT/SERT >1500 and NET/SERT > 1500).

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