Synthesis and structural characterization of new bioactive ligands and their Bi(III) derivatives

Abstract

Five new carboxylic acid precursors bearing thiourea group and their corresponding bismuth(III) complexes were synthesized and characterized using CHNS and inductively coupled plasma analyses and infrared and NMR ( 1 H, 13 C) spectroscopies. Single-crystal X-ray diffraction analysis was also carried out for one of the precursors. The behaviour of the compounds was bioassayed for antibacterial, antifungal, antioxidant and enzyme (lipoxygenase, α-glycosidase and anti-urease) inhibition activities. It is concluded that the interaction of the compounds with bismuth enhances both the antimicrobial and enzyme inhibition activities. The synthesized compounds may prove to be good therapeutic agents.

Bioactive Heteroleptic Bismuth(V) Complexes: Synthesis, Structural Analysis and Binding Pattern Validation

“…The lowering of the wave number by 60–90 cm −1 for the symmetric and asymmetric carboxylate stretching absorption, on the formation of bismuth(V) carboxylates, indicates that metal–carboxylate linkage has been established. The other characteristic IR absorption bands observed are; 470–495 and 420–450 cm −1 corresponding to C‐Bi out of plane deformations and Bi‐O stretching mode vibrations which are consistent with the literature values . The Δν (νCO 2 asymm − νCO 2 symm ) values fall in range 150–250 cm −1 depicting that the carboxylato ligands adopt a bidentate or anisobidentate binding mode for ( 1 – 7 ) as earlier reports manifested and further authentication came through crystallographic data .…”

Synthesis and Structural Characterization of Bioactive Ferrocenyl Substituted Hydrazones

“…Ferrocene, being phenomenal in the field of medicinal organometallic chemistry [14,15], engrossed the attention of researchers based on its unusual properties such as aromaticity, low toxicity, stability and redox activity, therefore, the core is an attractive pharmacophore in drug design [16,17]. Considering the above mentioned structural aspects and in continuation to our previous research work [18][19][20][21][22], we report herein the design and synthesis of a new series of ferrocenyl substituted hydrazones with a few exceptions that have already been reported [23,24]. In these structures, the ferrocene core is connected to heterocyclic and non-heterocyclic moieties through a hydrazine linkage.…”

Synthesis, antimicrobial activity, urease inhibition and molecular docking studies of new proline linked thiourea derivatives

“…12 Metal complexes of these thiourea derivatives are utilized in supramolecular chemistry, homogenous catalysis, magnetic materials and chemical vapor deposition. 11,13 Keeping in view the above aspects and in the continuation of our previous research work, [14][15] we report herein the synthesis, structural characterization and biological activities of some substituted thiourea derivatives (I a-I e ).…”