volume 25, issue 20, P5603-5612 2017
DOI: 10.1016/j.bmc.2017.08.035
View full text

Abstract: This study describes the synthesis and radiosynthesis of eight new [F]fluoro-inositol-based radiotracers in myo- and scyllo-inositol configuration. These radiotracers are equipped with a propyl linker bearing fluorine-18. This fluorinated arm is either on a hydroxyl group, i.e. O-alkylated inositols, or on the cyclohexyl backbone, i.e. C-branched derivatives. To modulate lipophilicity, inositols were synthesized in acetylated or hydroxylated form. Automated radiosynthesis was performed on the AllInOne module a…

Expand abstract