Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates

Design, Synthesis, Pharmacological Evaluation and Molecular Docking Studies of Substituted Oxadiazolyl-2-Oxoindolinylidene Propane Hydrazide Derivatives

“…18 Those compounds, which showed good results in antiinflammatory and analgesic activity, were screened for their ulcerogenic activity. The tested compounds exhibited activity in the range of 0.14 to 0.56, whereas standard drug indomethacin presented very high severity index of 1.25.…”

“…18 Sprague Dawley rats were used for this study; seventeen groups with six rats per group were formed. All test samples were administered to animals at 100 mg kg −1 dosage, as suspension in 0.5% carboxymethyl cellulose in water.…”

“…Gastric mucosa of the rats was examined by means of a four times binocular magnifier and the lesions were counted according to earlier reported method. 18 Accordingly, the mean score of each treated group minus the mean score of the control group was considered to determine the severity index of gastric damage for compounds under study.…”

“…13 In the past, many indole and 1,3,4-oxadiazole derivatives showed potential for anti-inflammatory and analgesic activity in animal model of inflammation and pain. [14][15][16][17][18] Compound The need for newer drug molecule and success of hybrid approach compelled us for development of some new NSAIDs. The target moieties selected for formation of a hybrid drug was based on our previous literature study, and it was found that indole and oxadiazole nuclei possess analgesic and anti-inflammatory properties and thus it was found worth to prepare a hybrid derivative from these moieties.…”

A Convenient One-Pot Biginelli Reaction Catalyzed by Y(OAc)3: An Improved Protocol for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and Their Sulfur Analogues

“…Hence, they are classified as one of the most important groups of drug like scaffold. [4][5][6][7] A recent emphasis in this perspective has been the identification of the structurally simple DHPM derivative viz., monastrol as a mitotic kinesin Eg5 motor protein inhibitor for the development of anticancer drugs. 8 The great potential of DHPMs in biological and pharmaceutical fields has accordingly triggered growing interest in their synthetic study.…”