Synthesis and Molecular modeling of some new chalcones derived from coumarine as CDC25 phosphatases inhibitors

Dridi, Delel; Abdelwahab, Ahmed B.; Bana, Emilie; Chaimbault, Patrick; Meganem, Faouzi; Kirsch, Gilbert

doi:10.13171/mjc.5.1/0160112/kirsch

Cited by 4 publications

(1 citation statement)

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“…Delel et al [103] reported the anticancer activity of coumarin-chalcones against CDC25 phosphatase. Hybrids with chlorine and bromine at the 6 th position on coumarin ring (21) inhibit CDC25A than hybrids with methoxy group at the 6 th position of coumarin ring.…”

Section: Anticancer Activitymentioning

confidence: 99%

Recent Strategies for Efficient Synthesis and Biological Activities of Coumarin-Chalcone Derivatives

Konidala

Kotra

2020

Asian J Pharm Clin Res

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Coumarins and chalcones are potential pharmacological and biologically active molecules obtained from natural source. Coumarins have predominant pharmacological activities such as antidiabetic, antitumor, and anti-inflammatory activity. Chalcones are also one of the naturally occurring pharmacologically vital molecules with different activities such as anti-inflammatory, antitumor, antimicrobial, and antimalarial activity. Literature reveals that a huge number of coumarinyl chalcone derivatives have various pharmacological activities. Coumarinyl chalcone derivatives gained more prominence due to their significant biological activities. This work explains the current information about synthesis techniques, pharmacological importance, and clinical applications of coumarinyl chalcone derivatives.

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Section: Anticancer Activitymentioning

confidence: 99%