Synthesis and molecular characterization of chitosan/starch blends based polyurethanes

Javaid, Muhammad Asif; Zia, Khalid Mahmood; Zafar, Kashif; Khosa, Muhammad Kaleem; Akram, Nadia; Ajmal, Muhammad; Imran, Muhammad; Iqbal, Muhammad N.

doi:10.1016/j.ijbiomac.2019.12.234

Cited by 36 publications

(13 citation statements)

References 43 publications

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“…These new biomaterials have many advantages over conventional biomaterials such as repairing of spinal and peripheral nerves, damaged cranial, connective tissues and skin, as well as they provide the relief from long-term health risks too (Javaid et al, 2020). Due to the electrical response of conducting polymers, feasibility for stimulation of chosen tissue, time-controlled drug release and inspiration of propagation or differentiation of numerous cell categories occurs (Kenry & Liu, 2018).…”

Section: Advantag E S Of B Iodeg R Adab Le Conduc Ting P Olymer S Omentioning

confidence: 99%

“…Tailoring of degradation products and degradation rates can be tuned according to structure, composition and molar mass (Englert et al, 2018; Hacker et al, 2019). Some most common biodegradable polymers are widely studied such as polyglycolide (PGA) (Liu et al, 2019), polylactide (PLA) (Bergström & Hayman, 2016; Chen et al, 2018), polycaprolactam (PCL) (Fakhri et al, 2018) and polyurethane (PU) (Javaid et al, 2020) (Figure 1).…”

Section: Biomaterialsmentioning

confidence: 99%

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Biodegradable conducting polymeric materials for biomedical applications: a review

2020

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Biomaterials are natural or synthetic materials that are biodegradable and interact cordially with biological systems (Qu et al., 2019). These can be well-defined as a material envisioned to interface with biological systems for evaluation, treatment and replacement of organs, tissues or function of the body (Basu & Ghosh, 2017; Reis et al., 2016). They play a key role in the human health system which is attained from nature or the environment (Mir et al., 2018). Generally, biopolymers are the main class of biomaterials as biopolymers are biocompatible, biodegradable and human body-friendly (Rebelo et al., 2017). These biopolymers are further classified as biodegradable and non-biodegradable according to their nature (Andreeßen & Steinbüchel, 2019; Kabir et al., 2020). Due to their outstanding biocompatibility, biodegradable polymers are known as the best candidate for biomedical applications such as drug delivery systems, vascular grafts, surgical sutures, artificial skin, bone fixation devices, gene delivery systems, tissue engineering and diagnostic applications. Biomedical engineering is an attractive branch which deals with engineering and biology together to put on engineering materials and rudiments in the field of healthcare and medicine. Tissue engineering is also a part of it that fulfils the purposes of recovering or exchange failing or broken body tissue by merging cells, scaffolds and bioactive molecules. Scaffolds should combine various functions such as biodegradability, biocompatibility, ideal mechanical strength, adequate porosity for small molecule transportation, controllability, implantation and sterilization. Hence, natural polymers such as gelatin and chitosan are the perfect match for scaffold fabrication and synthetic aliphatic polyesters too. However, these revealed poor hydrophilicity which limits the cell attachment on surfaces and lack of sites for covalent bonding. While having their biodegradable nature, biopolymers or conventional polymers are insulators in nature so that limits the use in some biomedical applications where conducting properties of biomaterials is indispensable (George et al., 2020). In many applications of implants in the body, such as in bone fixing materials, dental materials and bone substitution materials, there is a need for such type of material showing long-term stable performance. In other applications such as controlled drug delivery, regenerative medicine, tissue engineering

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Section: Advantag E S Of B Iodeg R Adab Le Conduc Ting P Olymer S Omentioning

confidence: 99%

Section: Biomaterialsmentioning

confidence: 99%

Biodegradable conducting polymeric materials for biomedical applications: a review

2020

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“…Bioactivity in the material can be improved by the utilization of biomolecules such as chitosan [ 3 ] and alginate. Because of this ability, one can synthesize a large number of composite materials of PU with desired properties such as biodegradability, biocompatibility, thermal stability, and durability [ 4 ]. PU products range from coatings to elastomers, foams, and adhesives.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and Hemolytic Activity Studies of Synthesized Alginate-Based Polyurethanes

et al. 2022

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Many investigators have focused on the development of biocompatible polyurethanes by chemical reaction of functional groups contained in a spacer and introduced in the PU backbone or by a grafting method on graft polymerization of functional groups. In this study, alginate-based polyurethane (PU) composites were synthesized via step-growth polymerization by the reaction of hydroxyl-terminated polybutadiene (HTPB) and hexamethylene diisocyanate (HMDI). The polymer chains were further extended with blends of 1,4-butanediol (1,4-BDO) and alginate (ALG) with different mole ratios. The structures of the prepared PU samples were elucidated with FTIR and 1H NMR spectroscopy. The crystallinity of the prepared samples was evaluated with the help of X-ray diffraction (XRD). The XRD results reveal that the crystallinity of the PU samples increases when the concentration of alginate increases. Thermogravimetric (TGA) results show that samples containing a higher amount of alginate possess higher thermal stability. ALG-based PU composite samples show more biocompatibility and less hemolytic activity. Mechanical properties, contact angle, and water absorption (%) were also greatly affected.

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“…Zia et al suggested that an appropriate reduction of Chit chains, such as due to H 2 O 2 treatment, allowed introducing chitosan into chains of PUR elastomers [49]. Other authors stated that chitosan particles can be introduced into the polyurethane structure, claiming that neat chitosan in particles' forms can react with the isocyanate by -OH and -NH 2 groups; whereas the low molecular weight of the obtained polyurethanes suggested rather the formation of the PUR/Chit composites with hydrogen-bonded chitosan particles (as indicated by FTIR and NMR results) [50].…”

Section: Introductionmentioning

confidence: 99%

“…PUR/Chit composites are also often additionally modified with various additives, such as by adding: Starch [50], curcumin [51], β-tricalcium phosphate [52], zinc oxide nanoparticles [41], anatase titania [53], carbon nanotubes [54], graphene oxide [55], polyvinylpyrrolidone [56], and others. Systems for medical purposes are particularly extended with various additions [52,[57][58][59].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Chitosan on the Chemical Structure, Morphology, and Selected Properties of Polyurethane/Chitosan Composites

Piotrowska-Kirschling

Brzeska

2020

Polymers

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Materials science is an interdisciplinary area of studies. This science focuses on the influence of the physico-chemical properties of materials on their application in human everyday lives. The materials’ synthesis should be developed in accordance with sustainable development. Polyurethanes (PUR) represent a significant consumption of plastic in the world. Modification of PUR, e.g., with polysaccharide of natural origin (chitosan, Chit), should have a positive effect on their functional properties and degradability in the natural environment. The basic parameters affecting the scope and direction of changes are the size and quantity of the chitosan particles. The impact assessment of chitosan on the chemical structure, morphology, thermal properties, crystallinity, mechanical properties, flammability, water sorption, adsorption properties, degradability, and biological activity of PUR/Chit composites (without other additives) is discussed in this article. To the best of our knowledge, recent literature does not contain a study discussing the direct impact of the presence of chitosan in the structure of PUR/Chit composite on its properties, regardless of the intended uses. This paper provides an overview of publications, which presents the results of a study on the effect of adding chitosan in polyurethane/chitosan composites without other additives on the properties of polyurethane.

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Synthesis and molecular characterization of chitosan/starch blends based polyurethanes

Cited by 36 publications

References 43 publications

Biodegradable conducting polymeric materials for biomedical applications: a review

Biodegradable conducting polymeric materials for biomedical applications: a review

Biocompatibility and Hemolytic Activity Studies of Synthesized Alginate-Based Polyurethanes

The Effect of Chitosan on the Chemical Structure, Morphology, and Selected Properties of Polyurethane/Chitosan Composites

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