Synthesis and in vitro antitumour activity of carboplatin analogues containing functional handles compatible for conjugation to drug delivery systems

Recnik, Lisa‐Maria; Cantelli, Christophe; Fersing, Cyril; Gongora, Céline; Pouget, Jean‐Pierre; Lisowski, Vincent

doi:10.1016/j.bmcl.2020.127527

Cited by 7 publications

(8 citation statements)

References 21 publications

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“…This allows for the production of a wide range of polyethylenes without polymer agglomeration. To achieve this, molecular single-site catalysts of MOFs, such as cationexchanged MFU-4l (Zn 5 Cl 4 (BTDD) 3 and H 2 BTDD = bis(1H-1,2,3,-triazolo [4,5-b],[4′,5′-i])dibenzo [1,4]dioxin), which contain active metal cations (Ti, V, Cr, or Co) that can be replaced by Zn 2+ ions, were used to control reactivity with a high degree during olefin polymerization. The alkylaluminum cocatalysts were necessary to produce gas-phase ethylene polymerization.…”

Section: Polymerization Reactions By Mof Catalystsmentioning

confidence: 99%

“…Catalysts speed up a chemical reaction by providing lower activation energy without participating in the reaction. The word “catalysis” originates from Greek “κατα” and “λυσισ” which means “down” and “loosening”, respectively. − With the catalyst providing for a rapid and efficient method, the reactions were improved toward a better rate and selectivity at generally gentle conditions . Catalytic technologies have been a fundamental part of modern human advancement. − The Egyptians and the Sumerian utilized catalytic forms to produce alcohol.…”

Section: Introductionmentioning

confidence: 99%

“…For centuries, the ancient Greek, classic Roman, and Islamic empires created the agricultural revolution by performing catalysis through controlled ammonia synthesis. Commercial production of base chemicals with large-scale production such as sulfuric acid by catalytic processes started the industrial revolution. ,− Due to their large-scale applications of catalysts, high price, and scarce reserves, development of a cost-effective, high-activity, nonprecious metal-based electrocatalysts is urgent because of enhanced activities, high stability, and catalytic activity. − …”

Section: Introductionmentioning

confidence: 99%

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MOFs as Versatile Catalysts: Synthesis Strategies and Applications in Value-Added Compound Production

et al. 2023

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Catalysts played a crucial role in advancing modern human civilization, from ancient times to the industrial revolution. Due to high cost and limited availability of traditional catalysts, there is a need to develop cost-effective, high-activity, and nonprecious metal-based electrocatalysts. Metal−organic frameworks (MOFs) have emerged as an ideal candidate for heterogeneous catalysis due to their physicochemical properties, hybrid inorganic/organic structures, uncoordinated metal sites, and accessible organic sections. MOFs are high nanoporous crystalline materials that can be used as catalysts to facilitate polymerization reactions. Their chemical and structural diversity make them effective for various reactions compared to traditional catalysts. MOFs have been applied in gas storage and separation, ion-exchange, drug delivery, luminescence, sensing, nanofilters, water purification, and catalysis. The review focuses on MOF-enabled heterogeneous catalysis for value-added compound production, including alcohol oxidation, olefin oligomerization, and polymerization reactions. MOFs offer tunable porosity, high spatial density, and single-crystal XRD control over catalyst properties. In this review, MOFs were focused on reactions of CO 2 fixation, CO 2 reduction, and photoelectrochemical water splitting. Overall, MOFs have great potential as versatile catalysts for diverse applications in the future.

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Section: Polymerization Reactions By Mof Catalystsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MOFs as Versatile Catalysts: Synthesis Strategies and Applications in Value-Added Compound Production

et al. 2023

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“…Combining CARB with different chemotherapy drugs has resulted in a higher therapeutic index in the treatment of advanced cancers such as in advanced ovarian cancer with CARB/paclitaxel, in advanced bladder carcinoma with CARB/gemcitabine, and in advanced nonsmall-cell lung cancer with CARB/paclitaxel/gemcitabine combination chemotherapy . However, CARB has very short biological half-life and, similar to FUDR, it suffers high systemic toxicity . These factors, combined with their existing approval for use in the clinic, make CARB and FUDR prime candidates for targeted drug delivery, to enhance therapeutic efficiency by using smaller dosages that are targeted to the disease locus to minimize off-target effects.…”

Section: Introductionmentioning

confidence: 99%

“… 13 However, CARB has very short biological half-life and, similar to FUDR, it suffers high systemic toxicity. 14 These factors, combined with their existing approval for use in the clinic, make CARB and FUDR prime candidates for targeted drug delivery, to enhance therapeutic efficiency by using smaller dosages that are targeted to the disease locus to minimize off-target effects.…”

Section: Introductionmentioning

confidence: 99%

Glycopolymer-Functionalized MOF-808 Nanoparticles as a Cancer-Targeted Dual Drug Delivery System for Carboplatin and Floxuridine

Duman

Monaco

Foulkes

et al. 2022

ACS Appl. Nano Mater.

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Codelivery of chemotherapeutics via nanomaterials has attracted much attention over the last decades due to improved drug delivery to tumor tissues, decreased systemic effects, and increased therapeutic efficacies. High porosities, large pore volumes and surface areas, and tunable structures have positioned metal−organic frameworks (MOFs) as promising drug delivery systems (DDSs). In particular, nanoscale Zr-linked MOFs such as MOF-808 offer notable advantages for biomedical applications such as high porosity, good stability, and biocompatibility. In this study, we report efficient dual drug delivery of floxuridine (FUDR) and carboplatin (CARB) loaded in MOF-808 nanoparticles to cancer cells. The nanoparticles were further functionalized by a poly(acrylic acid-mannose acrylamide) (PAAMAM) glycopolymer coating to obtain a highly selective DDS in cancer cells and enhance the therapeutic efficacy of chemotherapy. While MOF-808 was found to enhance the individual therapeutic effects of FUDR and CARB toward cancerous cells, combining FUDR and CARB was seen to cause a synergistic effect, further enhancing the cytotoxicity of the free drugs. Enhancement of CARB loading and therefore cytotoxicity of the CARB-loaded MOFs could be induced through a modified activation protocol, while coating of MOF-808 with the PAAMAM glycopolymer increased the uptake of the nanoparticles in cancer cells used in the study and offered a particularly significant selective drug delivery with high cytotoxicity in HepG2 human hepatocellular carcinoma cells. These results show how the enhancement of cytotoxicity is possible through both nanovector delivery and synergistic treatment, and that MOF-808 is a viable candidate for future drug delivery studies.

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DFT study of carboplatin encapsulation interactions with carboxylated carbon nanotubes and conjugated to folic acid for targeted nano delivery systems

Hani¹,

Alsubaiyel²,

Huwaimel³

et al. 2023

Alexandria Engineering Journal

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Synthesis and in vitro antitumour activity of carboplatin analogues containing functional handles compatible for conjugation to drug delivery systems

Cited by 7 publications

References 21 publications

MOFs as Versatile Catalysts: Synthesis Strategies and Applications in Value-Added Compound Production

MOFs as Versatile Catalysts: Synthesis Strategies and Applications in Value-Added Compound Production

Glycopolymer-Functionalized MOF-808 Nanoparticles as a Cancer-Targeted Dual Drug Delivery System for Carboplatin and Floxuridine

DFT study of carboplatin encapsulation interactions with carboxylated carbon nanotubes and conjugated to folic acid for targeted nano delivery systems

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