2018
DOI: 10.1590/s2175-97902018000317044 View full text |Buy / Rent full text
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Abstract: As our ongoing work on research of anti-HIV-1 inhibitors, fifteen N-arylsulfonyl-3-formylindoles (3ao) were designed and prepared through two step synthetic route. Firstly, 3-formylindoles (2a-c) were synthesized via the Vilsmeier-Haack reaction. Subsequently, treatment of 2a-c with the appropriate arylsulfonyl chlorides led to the corresponding target compounds in excellent yields. All analogues were also preliminary evaluated in vitro for their inhibitory activity against HIV-1 replication. Among of all the … Show more

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“…Indole is an important nitrogen-containing heterocyclic compound. Indole and indole derivatives have a broad spectrum of biological activities such as antifungal [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ], antibacterial [ 27 , 28 , 29 ], antimycobacterial [ 30 ], antitubercular [ 31 , 32 , 33 ], antioxidant [ 34 ], antimalarial [ 35 , 36 , 37 ], antiviral [ 38 , 39 , 40 , 41 ], anti-leishmanial [ 42 , 43 ], anti-inflammatory [ 44 ], and anti-tumor [ 45 , 46 , 47 ] activities. The design and synthesis of new indole derivatives with excellent biological activity is one of the emerging fields in pharmaceutical chemistry.…”
Section: Introductionmentioning
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“…Indole is an important nitrogen-containing heterocyclic compound. Indole and indole derivatives have a broad spectrum of biological activities such as antifungal [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ], antibacterial [ 27 , 28 , 29 ], antimycobacterial [ 30 ], antitubercular [ 31 , 32 , 33 ], antioxidant [ 34 ], antimalarial [ 35 , 36 , 37 ], antiviral [ 38 , 39 , 40 , 41 ], anti-leishmanial [ 42 , 43 ], anti-inflammatory [ 44 ], and anti-tumor [ 45 , 46 , 47 ] activities. The design and synthesis of new indole derivatives with excellent biological activity is one of the emerging fields in pharmaceutical chemistry.…”
Section: Introductionmentioning