Synthesis and in vitro and in vivo evaluations of poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) magnetic nanoparticles containing doxorubicin as a potential targeted drug delivery system

A biotechnological perspective on the application of iron oxide nanoparticles

“…3. More specifically, SPIONs-assisted drug delivery systems have been designed to deliver peptides, DNA molecules, and chemotherapeutic, radioactive, and hyperthermic drugs [151]. The most recent delivery systems are focused on drugs that are anti-infective, blood clot-dissolving, anti-inflammatory, anti-arthritic, and paralysis-inducing; these systems also focus on photodynamic therapy and stem cell differentiating/tracking [70].…”

A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development

“…Using nano-carriers, Lipodisq™ we were able to deliver the required concentration of IAXO-102 which has poor solubility in organic solvents. A similar nano-particle approaches to drug delivery has been used for administration of anticancer compounds, such as Doxorubicin for targeted delivery [24]. Pharmacokinetic studies using IAXO-102-FITC demonstrated that the dose of 3 mg/kg was sufficient to produce stable signal and drug distribution among several organs.…”

Multifunctional Fluorescent-Magnetic Polymeric Colloidal Particles: Preparations and Bioanalytical Applications

“…In which, the nanoparticles are preferentially accumulated at specific tumor sites through passive targeting. 53 In order to clarify the location of FMPs in the cells, the fluorescence microscopy and electron microscopy were performed. It was observed that the particles were located inside the cells as well as on the cell surface as presented in Figure 8B 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 25 coated with aminopropyl containing silica or partly carboxymethyl CS (γ-Fe 2 O 3 -SiO 2 -AP-CMCS) were used for both MR and fluorescent molecular imaging as a powerful tool to study the interaction of the nanoparticles with biological systems.…”