Synthesis and <i>in vitro</i> preliminary evaluation of prostate-specific membrane antigen targeted upconversion nanoparticles as a first step towards radio/fluorescence-guided surgery of prostate cancer

Cordonnier, Axel; Boyer, Damien; Besse, Sophie; Valleix, R.; Mahiou, Rachid; Quintana, Mercedes; Briat, Arnaud; Benbakkar, Mhammed; Penault‐Llorca, Frédérique; Maisonial-Besset, Aurélie; Maunit, Benoı̂t; Tarrit, Sébastien; Vivier, Magali; Witkowski, Tiffany; Mazuel, Leslie; Degoul, Françoise; Miot-Noirault, Élisabeth; Chezal, Jean‐Michel

doi:10.1039/d1tb00777g

Cited by 16 publications

(9 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the typical challenge is that it has insufficient light intensity and is poisonous to biological cells; therefore, its structure and surface must be modified [2]. Many scholars have proposed doping Mo 3+ , Cu 2+ [3,4], and other metal ions in the NaYF 4 :Yb 3+ /Er 3+ unit cell to increase the luminous intensity [5,6], but the effect is not significant. Others have offered sliver doping [7], which has a large impact as well; however, sliver is poisonous to cells, may cause cell death without targeting, and cannot be employed in biology.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Zhang

Zang

et al. 2022

IJMS

View full text Add to dashboard Cite

Two key concerns exist in contemporary cancer chemotherapy in clinic: limited therapeutic efficiency and substantial side effects in patients. In recent years, researchers have been investigating a revolutionary cancer treatment technique, and photodynamic therapy (PDT) has been proposed by many scholars. A drug for photodynamic cancer treatment was synthesized using the hydrothermal method, which has a high efficiency to release reactive oxygen species (ROS). It may also be utilized as a clear multi-modality bioimaging platform for photoacoustic imaging (PAI) due to its photothermal effect, computed tomography (CT), and magnetic resonance imaging (MRI). When compared to single-modality imaging, multi-modality imaging delivers far more thorough and precise details for cancer diagnosis. Furthermore, Au-doped up-conversion nanoparticles (UCNPs) have an exceptionally high luminous intensity. The Au-doped UCNPs, in particular, are non-toxic to tissues without laser at an 808 nm wavelength, endowing the as-prepared medications with outstanding therapeutic efficacy but exceptionally low side effects. These findings may encourage fresh effective imaging-guided approaches to meet the goal of photodynamic cancer therapy to be created.

show abstract

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Zhang

Zang

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Many scholars have proposed that they can be used in biological imaging because they offer significant advantages in the fight against major diseases, such as cancer [ 1 , 2 , 3 ]. However, a common difficulty is that they have insufficient luminous intensity and are toxic to biological cells, so it is necessary to modify their structure and modify their surface [ 4 ]. To mitigate this problem, several imaging probes were combined into a single multi-modality imaging system, even with some considerable restrictions such as the need to use a sophisticated synthetic processes and the heterogeneity of the resulting nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Rare-Earth Nanomaterials Ag-Doped NaYF4:Yb3+/Er3+@NaYF4:Nd3+@NaGdF4 for In Vivo Imaging

Zhang

Zang

et al. 2022

Nanomaterials

View full text Add to dashboard Cite

In this study. a novel near-infrared fluorescent-driven contrast agent (Ag-doped NaYF4:Yb3+/Er3+@NaYF4:Nd3+@NaGdF4) was synthesized using a coprecipitation-hydrothermal-solvothermal-solvothermal (CHSS) method. The results shows that hexagonal NaYF4:Yb3+/Er3+ with a diameter of 300 nm was successfully synthesized by the CHSS method. The new contrast agent was characterized using scanning electron microscopy, fluorescence spectrometry, transmission electron microscopy, energy-dispersive spectrometry and ultraviolet-visible light diffuse reflectance absorption spectroscopy. Even at low concentrations (0.2 M), this proposed contrast agent can be excited by near-infrared light with a wavelength of 980 nm and emits a dazzling green light with a wavelength of 540 nm, and the comparison of the luminescence intensity proves that doping with silver increases the luminescence intensity of the upconverted nanomaterial by nearly 13 times based on the calculated quantum yield. TEM images show the successful preparation of silver nanoparticles with a diameter of 30 nm, and the energy spectrum shows the successful doping of silver nanoparticles and the successful preparation of the core-shell structure of NaYF4:Yb3+/Er3+@NaYF4:Nd3+@NaGdF4. Furthermore, the mechanism of the increased luminous intensity has been studied using simulation calculations. Finally, cytotoxicity tests were used to test material which was modified by 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG2K), and the biocompatibility was significantly improved, meeting the standard for biological applications.

show abstract

“…Ligand exchange, or ligand displacement, is widely used for this purpose . Several polymers have been reported as potential ligand candidates, capable of making UCNPs hydrophilic and biocompatible such as poly(allylamine hydrochloride), poly(acrylic acid), , polyethylene glycol functionalized with anchoring groups, − polyethylenimine, and poly(amidoamine) …”

Section: Introductionmentioning

confidence: 99%

Design Traits for Diblock Copolymer Coating Properties on NaGdF₄ Upconversion Nanoparticles

Pham

Walsh

2022

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

Inorganic upconversion nanoparticles used in biological and medical applications are typically coated with materials to make these particles biocompatible, colloidally stable in aqueous media, and bioactive. However, the design of the molecules used in this coating must be carefully tuned to achieve these desired properties, and the molecular-scale design rules required for this are not known. In this work, a molecular dynamics simulation strategy is introduced to predict the structures and properties of a family of diblock copolymers that are used to coat the surface of upconversion nanoparticles in liquid water. These polymers comprise blocks of poly(oligo (ethylene glycol) methyl ether acrylate) and monoacryloxy ethyl phosphate, where the length of the former block is varied to have 6, 13, 35, and 55 units. The optimal polymer size for a range of properties is identified by modeling their interactions with the aqueous NaGdF4 interface. The simulations suggest that interparticle aggregation is likely for the smaller polymers and that intrachain folding effects in the larger polymers strongly influence the polymer/inorganic interaction. This in turn affects the structure of the polymer/solvent interface and consequently governs the efficiency of bioconjugation for these coated nanoparticles. The outward presentation of carboxylate groups to the solvent is crucial to the antibody binding efficiency, and this was predicted to be significantly reduced for larger chains, consistent with recent experimental data. Informed by this, mathematical models are formulated to predict the relation between polymer sizes and three key properties: surface charge, maximum loading, and maximum thickness of the coatings. This molecular simulation strategy is generally applicable to determine the optimal properties of polymer coatings prior to experiment.

show abstract

Synthesis and in vitro preliminary evaluation of prostate-specific membrane antigen targeted upconversion nanoparticles as a first step towards radio/fluorescence-guided surgery of prostate cancer

Abstract: Over the last decade, upconversion nanoparticles (UCNP) have been widely investigated in nanomedicine due to their high potential as imaging agents in the near-infrared (NIR) optical window of biological tissues....

Cited by 16 publications

References 51 publications

Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Synthesis of Rare-Earth Nanomaterials Ag-Doped NaYF4:Yb3+/Er3+@NaYF4:Nd3+@NaGdF4 for In Vivo Imaging

Design Traits for Diblock Copolymer Coating Properties on NaGdF₄ Upconversion Nanoparticles

Contact Info

Product

Resources

About

Synthesis and in vitro preliminary evaluation of prostate-specific membrane antigen targeted upconversion nanoparticles as a first step towards radio/fluorescence-guided surgery of prostate cancer

Abstract: Over the last decade, upconversion nanoparticles (UCNP) have been widely investigated in nanomedicine due to their high potential as imaging agents in the near-infrared (NIR) optical window of biological tissues....

Cited by 16 publications

References 51 publications

Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Synthesis of Rare-Earth Nanomaterials Ag-Doped NaYF4:Yb3+/Er3+@NaYF4:Nd3+@NaGdF4 for In Vivo Imaging

Design Traits for Diblock Copolymer Coating Properties on NaGdF4 Upconversion Nanoparticles

Contact Info

Product

Resources

About

Design Traits for Diblock Copolymer Coating Properties on NaGdF₄ Upconversion Nanoparticles