Synthesis and evaluation of pyridinium polyoxometalates as anti-HIV-1 agents

Wang, Shunyi; Sun, Wuji; Hu, Qin; Yan, Hong; Zeng, Yi

doi:10.1016/j.bmcl.2017.04.025

Cited by 21 publications

(15 citation statements)

References 27 publications

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“…[13]. Moreover, the sizes and globular structure of many POMs are similar to some water-soluble fullerene derivatives that show excellent anti-human immunodeficiency virus (HIV) activity [14,15]. Moreover, the sizes and globular structure of many POMs are similar to some water-soluble fullerene derivatives that show excellent anti-human immunodeficiency virus (HIV) activity [14,15].…”

Section: Introductionmentioning

confidence: 98%

Preparation of polyoxometalate-doped aminosilane-modified silicate hybrid as a new barrier of chem-bio toxicant

Chang

Wang

2019

Journal of Inorganic Biochemistry

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A B S T R A C T Nanohybrid membranes based on the Keggin-type polyoxometalate (POM) H 5 PV 2 Mo 10 O 40 and aminosilanemodified silicate (Ormosil and Ormosil(NR 4 + Cl − )) hybrids were synthesized as a new barrier to protect against simulants of chemical and biological toxicant. The 31 P NMR and XPS results indicated that POM was bound to the Ormosil and Ormosil(NR 4 + Cl − ) hybrids after impregnation. The antibacterial effects of the hybrids and hybrid-impregnated fabrics against Gram-negative and Gram-positive bacteria were investigated with zone of inhibition, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and platecounting method. The MIC/MBC values of Ormosil(NR 4 + Cl − )/POM and Ormosil/POM against bacteria were 0.267/2.67 and 2.67/26.7, respectively, and the percentage reduction of bacteria was approximately 100% after 20 laundry cycles of their fabrics. The reaction products and mechanisms of the adsorptive degradation of 2chloroethylethylsulfide (CEES) by hybrids were investigated with 13 C NMR. The results of this study showed that POM-doped Ormosil systems are capable of destroying bacteria and CEES. + Cl − )/POM hybrids, have proved advantageous as a new type of insoluble antimicrobial polymer, because they have a greater antimicrobial activity and better durability in water than other conventional antimicrobial polymers. They have proved kill a broad range https://doi.

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Section: Introductionmentioning

confidence: 98%

Preparation of polyoxometalate-doped aminosilane-modified silicate hybrid as a new barrier of chem-bio toxicant

Chang

Wang

2019

Journal of Inorganic Biochemistry

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“…pCMV-VSV-G Envelope Vector was kindly gifted by Dr. Rui Pedro Galao (King’s College London, London, UK). PT-1(K 6 HPTi 2 W 10 O 40 ) was synthesized by Dr. Yan Hong as previously described [ 28 , 29 ]. The structure information of PT-1 was deposited at the Cambridge Crystallographic Data Centre (CCDC: 1440344).…”

Section: Methodsmentioning

confidence: 99%

“…Since then, several groups have synthesized and identified a number of new generations of POMs with improved potency and reduced toxicity [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ], although the mechanisms remain unclear. We have previously identified the anti-HIV activity of a number of Keggin POMs and derivatives [ 28 ]. In the present work, we evaluated the potency and mechanism of action of a Keggin polyoxometalate PT-1 (K 6 HPTi 2 W 10 O 40 , Cambridge Crystallographic Data Centre, CCDC: 1440344) in the prevention of HIV-1 entry.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Human Immunodeficiency Virus Type 1 Entry by a Keggin Polyoxometalate

Wang

Zhang

et al. 2018

Viruses

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Here, we report the anti-human immunodeficiency virus (HIV) potency and underlying mechanisms of a Keggin polyoxometalate (PT-1, K6HPTi2W10O40). Our findings showed that PT-1 exhibited highly potent effects against a diverse group of HIV type 1 (HIV-1) strains and displayed low cytotoxicity and genotoxicity. The time-addition assay revealed that PT-1 acted at an early stage of infection, and these findings were supported by the observation that PT-1 had more potency against Env-pseudotyped virus than vesicular stomatitis virus glycoprotein (VSVG) pseudotyped virus. Surface plasmon resonance binding assays and flow cytometry analysis showed that PT-1 blocked the gp120 binding site in the CD4 receptor. Moreover, PT-1 bound directly to gp41 NHR (N36 peptide), thereby interrupting the core bundle formation of gp41. In conclusion, our data suggested that PT-1 may be developed as a new anti-HIV-1 agent through its effects on entry inhibition.

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“…It was found that polyisotungstate combined with β-lactam antibiotics could enhance the efficacy of antibiotics against drug-resistant strains. 7 Wang et al 10 synthesized a series of novel pyridines (A 7 Pti 2 W 10 O 40 ) by using PM-19 (K 7 PTi 2 W 10 W 40 ) as the lead compound. The single cycle pseudovirus infection test showed that the designed polyoxometalate pyridine had low toxicity to TZM BL cells and high inhibitory activity against HIV-1 virus.…”

Section: Introductionmentioning

confidence: 99%