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Cited by 30 publications
(19 citation statements)
References 37 publications
(52 reference statements)
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“…The tripeptides hippuryl-L-histidyl-L-leucine (van Platerink et al, 2007) and hippurylglycylglycine (Jafarian-Tehrani et al, 2000) are commonly employed as substrates for angiotensin converting enzyme (ACE; peptidyl-dipeptidase A; EC 3.4.15.1) and are hydrolyzed by dipeptidase activity leaving the stable HA. Circulating HAwill certainly be exposed to ACE since it is expressed mainly in lung, vascular endothelium and kidney (Femia et al, 2008). However, when HA is exposed to the gastrointestinal tract, it may not be stable.…”
Section: The Glycine Deportation Systemmentioning
confidence: 99%
“…The tripeptides hippuryl-L-histidyl-L-leucine (van Platerink et al, 2007) and hippurylglycylglycine (Jafarian-Tehrani et al, 2000) are commonly employed as substrates for angiotensin converting enzyme (ACE; peptidyl-dipeptidase A; EC 3.4.15.1) and are hydrolyzed by dipeptidase activity leaving the stable HA. Circulating HAwill certainly be exposed to ACE since it is expressed mainly in lung, vascular endothelium and kidney (Femia et al, 2008). However, when HA is exposed to the gastrointestinal tract, it may not be stable.…”
Section: The Glycine Deportation Systemmentioning
confidence: 99%
“…They incubated sections of explanted hearts from 3 patients with ischemic cardiomyopathy with 18 F-benzoyl-lisinopril and showed uptake adjacent to regions with collagen deposition. Also, lisinopril was labeled with 99m Tc and evaluated for myocardial ACE-1 targeting in ACE-1-overexpressing transgenic rats 58,59 ( Figure 4A). Using in vivo SPECT imaging, they confirmed higher radiotracer uptake in transgenic than in control animals.…”
Section: Imaging Myofibroblasts and Rasmentioning
confidence: 99%
“…This illustrates the difficulty of incorporating not only Tc-99m but its required chelating agent as well into relatively small molecules. A limited number of small molecules with a molecular weight of Ͻ500 Da have been radiolabeled and found to retain their biological activity, namely Tc-99m TRODAT for monitoring dopamine transporter densities (18) and a Tc-99m lisinopril analog that monitors angiotensin-converting enzyme densities (19). But it is a challenge, considering the number of successful I-123 small molecules that have retained an important aspect of the biological activity of the parent compound.…”
Section: Eckelmanmentioning
confidence: 99%
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