Synthesis and Crystal Structure of 4-n-Butyl-5-(4-methylphenyl)-2H-1,2,4-triazol-3(4H)-one

2-(4-Bromophenoxy)propanohydrazide

“…These are important intermediates in the synthesis of azoles under acidic or basic conditions (Akhtar et al, 2007a;Ahmad et al, 1996). In continuation of our previous studies (Akhtar et al, 2006;Akhtar et al, 2007b), the title compound, 2-(4-bromophenoxy)propane hydrazide,was synthesized as an intermediate in the synthesis of certain azole derivatives (Akhtar et al, 2008). The C-N bond length of 1.330 (3)Å is similar to C-N 1.321 (3) Å, indicating the single bond character.The N1 -N2 bond length of 1.415 (3) Å in the title compound is longer than the N-N distance [1.366 (3)Å] in the crystal structure of N-propionyl-N′-(3-hydroxy-2-naphthoyl)hydrazide (Zheng, 2008).…”

“…For carboxyhydrazide derivatives with biological activities, see: Belkadi & Othman (2006); Goswami et al (1984); Akhtar et al (2008); ; Ahmad et al (1996); Akhtar et al (2006); For related structures, see: Akhtar, Khawar Rauf et al (2007); Zheng (2008).…”

4-n-Butyl-3-(3-methylphenyl)-1H-1,2,4-triazol-5(4H)-one

“…For related literature, see: Akhtar et al (2006Akhtar et al ( , 2007Akhtar et al ( , 2008; Aoyama et al (1984); Al-Masoudi et al (2006); Demirbas et al (2002); Lin et al (2005); Torres et al (2005); Witkowski et al (1972).…”

“…As part of our on going research on the synthesis of biologically active heterocyclic compounds (Akhtar et al, 2006(Akhtar et al, , 2007(Akhtar et al, , 2008, the title compound (I) was synthesized by cyclodehydration of 4-n-butyl-1-(3-methylbenzoyl) semicarbazide under basic conditions (Akhtar et al, 2006) to evaluate its biological activities.…”

(R)-1-(4-Bromobenzoyl)-4-(1-phenylpropyl)thiosemicarbazide

“…Thiosemicarbazides have attracted much attention partly because of their biological activities such as antifungal (Mohareb et al, 2007), antibacterial (Kucukguzel et al, 2006), antiamoebic (Singh et al, 2005) antitubercular (Cardia et al,2006), corrosion inhibitors (Singh et al, 2003) and partly because of their use as intermediates in the synthesis of many biologically active heterocyclic compounds like 1,3,4-oxadiazoles (Dolman et al, 2006), 1,3,4-thiadiazoles (Jalilian et al,2000) and 1,2,4-triazole (Akhtar et al, 2007;Akhtar et al, 2006). The other important biologically active compounds synthesized from thiosemicarbazides include thiazoles, thiazines, thiadiazines, pyrazines and indazoles (Hassan et al, 2006).…”