Synthesis and characterizations of YZ-BDC:Eu<sup>3+</sup>,Tb<sup>3+</sup> nanothermometers for luminescence-based temperature sensing

We present a visual tool and facile method to detect MCF-7 breast cancer cells by using YVO4:Eu3+@silica-NH-GDA-IgG bio-nanocomplexes. To obtain these complexes, YVO4:Eu3+ nanoparticles with a uniform size of 10–25 nm have been prepared firstly by the hydrothermal process, followed by surface functionalization to be bio-compatible and conjugated with cancer cells. The YVO4:Eu3+@silica-NH-GDA-IgG nanoparticles exhibited an enhanced red emission at 618 nm under an excitation wavelength of 355 nm and were strongly coupled with MCF-7 breast cancer cells via biological conjugation. These bio-nanocomplexes showed a superior sensitiveness for MCF-7 cancer cell labelling with a detection percentage as high as 82%, while no HEK-293A healthy cells were probed under the same conditions of in vitro experiments. In addition, the detection percentage of MCF-7 breast cancer cells increased significantly via the functionalization and conjugation of YVO4:Eu3+ nanoparticles. The experimental results demonstrated that the YVO4:Eu3+@silica-NH-GDA-IgG bio-nanocomplexes can be used as a promising labelling agent for biomedical imaging and diagnostics.

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Synthesis and characterizations of YZ-BDC:Eu³⁺,Tb³⁺ nanothermometers for luminescence-based temperature sensing

Abstract: In the present work, nanothermometers based on amorphous zirconium metal–organic frameworks co-doped with rare-earth ions (YZ-BDC:Eu3+,Tb3+) with sizes of about 10–30 nm were successfully synthesized via a microwave-assisted hydrothermal method at 120 °C for 15 min.

Cited by 3 publications

References 38 publications

Microwave-assisted synthesis of Zr-based metal–organic frameworks and metal-organic cages

Microwave-assisted synthesis of Zr-based metal–organic frameworks and metal-organic cages

Persistent Luminescence Nanomaterials with Up-Down Conversion Modes for Power Battery Temperature Measurement

Synthesis and In Vitro Testing of YVO4:Eu3+@silica-NH-GDA-IgG Bio-Nano Complexes for Labelling MCF-7 Breast Cancer Cells

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Synthesis and characterizations of YZ-BDC:Eu3+,Tb3+ nanothermometers for luminescence-based temperature sensing

Abstract: In the present work, nanothermometers based on amorphous zirconium metal–organic frameworks co-doped with rare-earth ions (YZ-BDC:Eu3+,Tb3+) with sizes of about 10–30 nm were successfully synthesized via a microwave-assisted hydrothermal method at 120 °C for 15 min.

Cited by 3 publications

References 38 publications

Microwave-assisted synthesis of Zr-based metal–organic frameworks and metal-organic cages

Microwave-assisted synthesis of Zr-based metal–organic frameworks and metal-organic cages

Persistent Luminescence Nanomaterials with Up-Down Conversion Modes for Power Battery Temperature Measurement

Synthesis and In Vitro Testing of YVO4:Eu3+@silica-NH-GDA-IgG Bio-Nano Complexes for Labelling MCF-7 Breast Cancer Cells

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Synthesis and characterizations of YZ-BDC:Eu³⁺,Tb³⁺ nanothermometers for luminescence-based temperature sensing