Synthesis and Characterization of Water-Soluble Polythiophene Derivatives for Cell Imaging

Wang, Fengyan; Li, Meng; Wang, Bing; Zhang, Jiangyan; Cheng, Yongqiang; Liu, Libing; Lv, Fengting; Wang, Shu

doi:10.1038/srep07617

Cited by 39 publications

(35 citation statements)

References 43 publications

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“…The above result suggests that WSPTs exhibit lower cytotoxicity than metal/semiconducting quantum dots and organic fluorescent dyes (Fig. ) . The low cytotoxicity and good photostability of WSPTs make them a better choice for lysosome‐specific imaging materials and localization.…”

Section: Water‐soluble Cptmentioning

confidence: 86%

“…More recently, Wang et al have reported various water‐soluble CPT derivatives (WSPTs) such as PT, PT‐DDA, PT‐ADA and PT‐ADA‐PPR for cell imaging (Fig. ) …”

Section: Water‐soluble Cptmentioning

confidence: 99%

“…(C–F) Cell viability of A549 cells treated with the four WSPTs using a typical MTT assay. (Reproduced from Wang et al )…”

Section: Water‐soluble Cptmentioning

confidence: 99%

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Water-soluble ionic polythiophenes for biological and analytical applications

et al. 2016

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Ionic polythiophenes are important conjugated polymers because of their excellent optical properties and water solubility. They are classified as cationic, anionic and zwitterionic conjugated polyelectrolytes. This review article describes concisely their biological and analytical applications. The specific detection of different negatively charged biomolecules such as DNA and adenosine triphosphate, anions like halides and toxic pseudo-halide (CN − ) and environmental pollutants, e.g. surfactants, is discussed. The conformational changes of cationic polythiophenes (CPTs) induced by various analytes due to formation of ionic conjugates and the cooperative responses of all segments cause dominant signal amplification even in the presence of a small perturbation. In addition, reactive oxygen scavenging, antimicrobial photosensitizing and cell imaging applications of CPTs are documented. Use of anionic polythiophenes for sensing of protamine and cations like Cu 2+ and Ca 2+ is also discussed. Finally, sensing of DNA, peptides and surfactants by zwitterionic polythiophenes is included. The concluding part discusses future prospects.

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Section: Water‐soluble Cptmentioning

confidence: 86%

“…More recently, Wang et al have reported various water‐soluble CPT derivatives (WSPTs) such as PT, PT‐DDA, PT‐ADA and PT‐ADA‐PPR for cell imaging (Fig. ) …”

Section: Water‐soluble Cptmentioning

confidence: 99%

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Water-soluble ionic polythiophenes for biological and analytical applications

et al. 2016

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“…All organic solvents and anhydrous ferric chloride were bought from Sinopharm Chemical Reagent Beijing Co., Ltd. Monomer 1, 2 and PPR were prepared referring to reported synthetic methods. 35,36 MTT (methylthiazolyldiphenyl-tetrazolium bromide) and FBS (fetal bovine serum) were bought from Xinjingke Biotechnology Co., Ltd (Beijing, China). DMEM (Dulbecco's modied Eagle medium) used to culture cells was purchased from HyClone/Thermosher.…”

Section: Materials and Instrumentsmentioning

confidence: 99%

Novel polythiophene derivative for dual-channel cell imaging

Wang

Xia

et al. 2019

RSC Adv.

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“…The optical and electronic interplay of these molecular moieties is, however, more widely being taken advantage of in the field of optoelectronics and photovoltaics. 122,123 Examples of polymeric thiophene-porphyrin conjugates and complexes can be found in literature, where the interactions of these structural moieties give rise to optical readouts for detecting bacteria 124 and eukaryotic cells 125 , or where such compounds are used for photodynamic inactivation of bacteria 126 and fungi 127 .…”

Section: Oligothiophene Porphyrin Hybrids As Fluorescent Probesmentioning

confidence: 99%

Multimodal Porphyrin-Based Conjugates: Synthesis and characterization for applications as amyloid ligands, photodynamic therapy agents and chiroptical materials

Arja¹

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Organic compounds that interact both with certain biological targets and display specific photophysical properties can be utilized as molecular tools to visualize and possibly affect disease related processes taking place in living organisms. In this regard, porphyrins are a class of naturally occurring molecules that possess intriguingly interesting photophysical properties where they can act as luminescent probes by emitting detectable light, as well as photosensitizers in the light mediated therapy denoted photodynamic therapy. In this thesis, the porphyrin structure has been synthetically combined with other types of molecules to achieve compounds with desirable multimodal characteristics. During my doctoral studies at Chemistry department at Linköping university, several people have contributed to the scientific work that I carried out, helped me with the everyday matters or supported me in general. I would like to thank all these fantastic people and especially acknowledge some of them: Professor Peter Nilsson, my supervisor, for all the guidance and support through the years. You are an expert on helping me see the possibilities in seemingly tiny things that would eventually lead to fascinating research projects. Professor Peter Konradsson, my co-supervisor, for the help in navigating in the world of organic chemistry and for the all the philosophical discussions about the rest of the world. All the past and present members of the Nilsson group: Therése for always being the wise and calm ideal of a researcher; Hamid with his never-disturbed and inspiring enthusiasm in synthetic chemistry; the chatty and positive Bisse for all her advice on chemistry and life, and for all the enjoyable coffee breaks and lunches; Elisabet for being one of the few downright good people left in this world and surely one of the persons with the highest number of different interests; Hanna for the fruitful collaborations and pleasant company; Karin, Rozalyn, Leffe, Jeff, Andreas, Timmy and Mikaela for all the help and for all the memorable moments at works. Mathias Elgland, another downright good person with a plethora of positive qualities ranging from being an excellent chemist to a worthy friend. I am deeply grateful for all the scientific collaborations and the friendship along the side. Thank you for your most enjoyable company over my many years at Linköping university! Linda Lantz, my roomie and a dear colleague and a friend, for cheering my days with interesting scientific and even more interesting non-scientific talk. You inspire with you strong and independent angles of life philosophy. Marcus Bäck, for being a truly understanding and reliable friend and a helpful colleague, and for backing me up with "Det gör du rätt i". Jakob Wallgren for m/baking my days with all these splendid pastries and with your pleasant company! People in Organic chemistry corridor: Xiongyu Wu, a true sensei in chemistry; Yun, Tobias, Roger.

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Synthesis and Characterization of Water-Soluble Polythiophene Derivatives for Cell Imaging

Cited by 39 publications

References 43 publications

Water-soluble ionic polythiophenes for biological and analytical applications

Water-soluble ionic polythiophenes for biological and analytical applications

Novel polythiophene derivative for dual-channel cell imaging

Multimodal Porphyrin-Based Conjugates: Synthesis and characterization for applications as amyloid ligands, photodynamic therapy agents and chiroptical materials

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