Synthesis and characterization of some biologically active ruthenium(II) complexes of thiosemicarbazones of pyridine 2-aldehyde and thiophene 2-aldehyde involving some ring substituted 4-phenylthiosemicarbazides and 4-cyclohexylthiosemicarbazide. Crystal structure of cis-[Ru(PPh3)2(L6H)2](ClO4)2·2H2O [L6H=4-(cyclohexyl) thiosemicarbazone of pyridine 2-aldehyde]

Sengupta, Parbati; Dinda, Rupam; Ghosh, Saktiprosad; Sheldrick, William S.

doi:10.1016/s0277-5387(02)01363-3

Cited by 59 publications

(19 citation statements)

References 39 publications

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“…The spores which showed sensitivity against the chemicals also showed a similar trend in the production of mycelial dry weight. Out of the tested fungi, Alternaria triticina showed maximum sensitivity when the chemicals were mixed, followed by Alternaria brassicae and Fusarium udum ( 3 Cl 2 ]Cl 2 . For practical utility of this compound, the inhibiting capacity of the complexes were compared with the commercially available fungicide, dithane-M-45 (a broad fungicide) which is used in the inhibition of spore germination in the 0.1 -0.2% in the field condition limit for many fungi.…”

Section: Analysis Of Variance (Anova)mentioning

confidence: 99%

“…There has been an escalating interest in the study of this branch of chemistry due to its prominence in supramolecular chemistry, material chemistry, and biochemistry [1]. Macrocyclic complexes have also received special attention because of their versatile coordination behaviour and their pharmacological properties [2,3]. To overcome the alarming problem of microbial resistance to antibiotics, the discovery of novel active compounds against new targets is a matter of urgency [4].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization and Biological Activity of Monometallic Complexes of Germanium

Chaudhary¹,

Singh²,

Rawat³

2016

Int. J. Curr. Res. Chem. Pharm. Sci

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Monometallic Complexes of germanium(IV) with macrocyclic ligands have been synthesized and characterized by elemental analysis, molar conductance , infrared spectra, 1 H NMR and 13 C NMR spectral studies. The molar conductance of 10 −3 M solutions of these complexes at the room temperature indicates that the complexes are 1:2 electrolytes in nature. On the basis of chemical composition there presentation of the complexes as [Ge(OAML)nCl2]Cl2 (n=1-5) has been proposed. These synthesized complexes have also been tested against several species of pathogenic fungi and bacteria in order to evaluate their antimicrobial properties.

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Section: Analysis Of Variance (Anova)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Biological Activity of Monometallic Complexes of Germanium

Chaudhary¹,

Singh²,

Rawat³

2016

Int. J. Curr. Res. Chem. Pharm. Sci

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“…They have exhibited antitumorogenic activity by reducing the number and size of carcinogen induced colon tumors and play synergistic role on the activity of certain antitumor drugs, although the mechanism has not been completely clarified [31][32][33]. Ligands having nitrogen donors received considerable attention because of their mixed hard-soft donor character, versatile coordination behavior [34][35] and for their biological activity (i.e., toxicity against bacterial growth [36], anticancer [37] and other biochemical properties [38]). The coordination geometry and nature of donor atoms play key roles in determining the binding extent of complexes to DNA.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

Tak¹

2017

IJRASET

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Novel complexes of copper (II), cobalt (II) and nickel (II) with sulphapyridine and aminothiazole were synthesized and characterized using spectral and analytical techniques. The interaction of cobalt (II) complexes with herring sperm DNA has been performed using absorption titration, viscometric measurements and cyclic voltammetry. The protective activity of metal complexes has been carried out using arose gel electrophoresis. The results indicate that cobalt (II) complex bind to DNA via electrostatic or groove binding with binding constant K b = 4.5 x 10 4 M -1. The antioxidant activity for cobalt (II) complex was also checked. Keywords: hypochromism, peak potential and binding constant. I. INTRODUCTIONThe binding of metal complexes to DNA has been extensively studied over the past decade. Many coordination compounds are able to bind DNA as structural probes[1], DNA foot printing [2], DNA cleaving agents [3][4] and as potential anticancer drugs [5][6]. It is generally believed that many anticancer, antiviral, and antiseptic agents take action through binding DNA [4,[7][8], since the interaction between small molecules and DNA can often cause DNA damage in cancer cells, blocking the division of cancer cells and resulting in cell death [9][10][11]. Many studies indicate that transition metal complexes can bind to DNA via both covalent (replacement of labile coordinating ligand by nitrogen base of DNA (i.e. adenine, Cytosine, guanine, thymine) and or non covalent interaction (intercalation, electrostatic or groove binding) [12]. Many important applications of these complexes require that they can bind via intercalative mode or groove binding [13]. Therefore interaction of complexes especially with planar aromatic heterocyclic ligands, which can insert into the base pairs of DNA duplex has attracted considerable attention [14][15][16]. is an essential element widely distributed in biological system [6,[17][18]. Numerous cobalt complexes has been studied as hydrolytic agent for DNA cleavage [19-20], antitumor, antproli-ferative[21-23], antimicrobial[24-26] and antifungal [21,27], antiviral [28,29], antioxidant [12 ,30] and ant inflammatory activity [30]. They have exhibited antitumorogenic activity by reducing the number and size of carcinogen induced colon tumors and play synergistic role on the activity of certain antitumor drugs, although the mechanism has not been completely clarified [31][32][33]. Ligands having nitrogen donors received considerable attention because of their mixed hard-soft donor character, versatile coordination behavior [34][35] and for their biological activity (i.e., toxicity against bacterial growth [36], anticancer [37] and other biochemical properties [38]). The coordination geometry and nature of donor atoms play key roles in determining the binding extent of complexes to DNA. The importance of central metal ion at the core of the structure is noteworthy [39,40]. Many DNA heterocyclic compounds such as benzothiazole and benzopyra zine derivatives have been evaluated and f...

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“…Transition metal complexes of thiosemicarbazones possess some degree of cytotoxic activity [9]. The chemistry of complexes of ruthenium with thiosemicarbazones, which can coordinate to the metal either in neutral thione form or in the anionic thiolate form, has received attention in recent years primarily due to their varied coordination mode, novel electrochemical and electronic properties, as well as their biological importance [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral characterization and catalytic studies of new ruthenium(II) chalcone thiosemicarbazone complexes

Muthukumar

Viswanathamurthi

2010

Open Chemistry

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C NMR) methods. On the basis of data obtained, an octahedral structure was assigned for all of the complexes. The chalcone thiosemicarbazones behave as dianionic tridentate O, N, S donors and coordinate to ruthenium via the phenolic oxygen of chalcone, the imine nitrogen of thiosemicarbazone and thienol sulfur. The new complexes exhibit catalytic activity for the oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones and they were also found to be efficient catalysts for the transfer hydrogenation of carbonyl compounds.

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Cited by 59 publications

References 39 publications

Synthesis, Characterization and Biological Activity of Monometallic Complexes of Germanium

Synthesis, Characterization and Biological Activity of Monometallic Complexes of Germanium

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

Synthesis, spectral characterization and catalytic studies of new ruthenium(II) chalcone thiosemicarbazone complexes

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