Synthesis and characterization of SBA-16 type mesoporous materials containing amine groups

Feliczak-Guzik, Agnieszka; Jadach, Barbara; Piotrowska, H.; Murias, Marek; Lulek, Janina; Nowak, Izabela

doi:10.1016/j.micromeso.2015.09.006

Cited by 49 publications

(28 citation statements)

References 42 publications

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“…On the other hand, most SBA-16 particles exhibited an irregular shape (Fig. 2b) similar to the morphology found by Feliczak-guzik et al (2016) (Feliczak-guzik et al, 2016). The maximum Feret diameter of SBA-16 particles was between 5 and 10 µm.…”

Section: Resultssupporting

confidence: 78%

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

Adrover

Pedernera

Bonne

et al. 2020

Saudi Pharmaceutical Journal

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Albendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the improvement of the water solubility and dissolution rate of ABZ implies a great challenge for a more efficient treatment of hydatidosis. In this context, SBA-15 and SBA-16 ordered mesoporous silica materials were synthetized and loaded with ABZ. X-ray diffraction, FT-IR spectroscopy, nitrogen physisorption manometry, particle size distribution and scanning electronic microscopy were used to characterize unloaded and loaded materials (ABZ/SBA-15 and ABZ/SBA-16). The loaded ABZ amount in the carriers was estimated by elemental analysis. For the loaded materials, the drug solubility and release profile were evaluated. In addition, mathematical models were compared to explain the dissolution kinetics of ABZ from mesoporous solids. ABZ was successfully loaded into the mesopores. The amorphous state of the adsorbed ABZ was confirmed by differential scanning calorimetry that resulted in a notable increment in the dissolution rate compared to crystalline ABZ. Drug release behaviors were well simulated by the Weibull model for ABZ/SBA-15 and by the Gompertz function for pure ABZ and ABZ/SBA-16. The SBA-15 carrier exhibited the highest drug loading and dissolution rate becoming a promising material to improve ABZ bioavailability.

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Section: Resultssupporting

confidence: 78%

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

Adrover

Pedernera

Bonne

et al. 2020

Saudi Pharmaceutical Journal

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“…These data demonstrate that there was a reduction in surface area and pore volume, thus confirming the presence of Rutin on silica (i.e. SBET, DP and VP of 806 m 2 •g −1 , 6.6 nm, 0.60 cm 3 •g −1 ) to SBA-16 [14] [24]. The comparison between the DP of SBA-16 and…”

Section: Physicochemical and Morphological Characterizationsupporting

confidence: 68%

Preparation of the Rutin-SBA-16 Drug Delivery System

Karnopp¹,

Cardoso²,

Gonçalves³

et al. 2020

JBNB

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This study sets out a scheme for a controlled release delivery system using SBA-16 as a carrier matrix and Rutin as a drug (Rutin-SBA-16). Physicochemical characterizations were performed to confirm the structure of the SBA-16 for post-synthesis by scanning electron microscopy (SEM), Transmission Electron Microscopy (TEM) and X-ray Diffraction (XRD). The presence of Rutin-SBA-16 was confirmed by Fourier-transform infrared spectroscopy (FTIR) and Nitrogen adsorption-desorption isotherms at 77 K. The dissolution kinetics was evaluated by the Zero Order, First Order and Higuchi models, and Rutin quantification was carried out by High Performance Liquid Chromatography (HPLC). The best impregnation time, which was 8 hours, adsorbing 284 μg Rutin per mg of silica, and the maximum degree of dissolution occurred in a period of 20-25 h. The release kinetics of the Rutin was called Higuchi, and showed high linearity, with a correlation coefficient (R 2) of 0.999 compared with 0.905 and 0.980 of the zero order and first order models respectively. The study shows the benefits of Rutin-SBA-16 as a drug delivery system.

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“…The M1 sample showed higher textural parameter values as compared to those reported in [26], with A BET =795 m 2 .g -1 , V p =0.99 cm 3 .g -1 , and D BJH =6 nm, demonstrating optimal conditions for obtaining the SBA-15 mesoporous structure. The values of the textural parameters described in [27] for the SBA-16 structure indicated that the values obtained for A BET = 858 and 711 m 2 .g -1 , V p = 1.06 and 1.35 cm 3 .g -1 and D BJH = 5 and 7 nm for samples M2 and M5, respectively, were consistent with the literature. The samples M3 and M4 had the best surface area results of the synthesized structures, 1074 and 1075 m 2 .g -1 , respectively, and, in comparison to the other samples, they showed a tendency that samples with smaller pores presented bigger surface areas and vice-versa.…”

Section: Resultssupporting

confidence: 88%

Synthesis and characterization of mesoporous materials with SBA and MCM structure types

et al. 2019

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Mesoporous materials are promising structures for application in catalysis and adsorption due to high surface area and large pore size. Mesoporous materials were synthesized by the hydrothermal method with novel surfactants, distinct from those observed in the literature, in order to carry out a study of its structure and to obtain materials with better textural properties. The structures synthesized with the surfactants Igepal CO630 and Brij O20 presented the best results of specific surface area, 1074 and 1075 m2.g-1, respectively. The obtained materials were characterized by XRD, TG/DTG, N2 adsorption-desorption, and FTIR techniques. XRD patterns indicated that the highly ordered mesoporous silica structures, such as MCM-41 and MCM-48, using CTMABr as the structure-directing agent and the SBA-15, SBA-16 and other SBA structures using different block copolymers were obtained. Through N2 adsorption-desorption isotherms, it was observed type IV isotherms, attributed to mesoporous materials. The FTIR spectra presented similar behaviors with characteristic vibrational bands of MCM and SBA type materials.

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Synthesis and characterization of SBA-16 type mesoporous materials containing amine groups

Cited by 49 publications

References 42 publications

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

Preparation of the Rutin-SBA-16 Drug Delivery System

Synthesis and characterization of mesoporous materials with SBA and MCM structure types

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