Synthesis and characterization of hydroxyapatite nanoparticles

Cengiz, Burcu; Gökçe, Yavuz; Yıldız, Nuray; Aktaş, Zeki; Çalımlı, Ayla

doi:10.1016/j.colsurfa.2008.02.011

Cited by 196 publications

(88 citation statements)

References 18 publications

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“…Biodegradability and nontoxicity, especially mechanical properties, are important factors for scaffolds in hard-tissue engineering [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties of Chitosan-Starch Composite Filled Hydroxyapatite Micro- and Nanopowders

Rezaei‐Tavirani

Biazar

et al. 2011

Journal of Nanomaterials

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Hydroxyapatite is a biocompatible ceramic and reinforcing material for bone implantations. In this study, Starch-chitosan hydrogel was produced using the oxidation of starch solution and subsequently cross-linked with chitosan via reductive alkylation method (weight ratio (starch/chitosan): 0.38). The hydroxyapatite micropowders and nanopowders synthesized by sol-gel method (10, 20, 30, 40 %W) were composited to hydrogels and were investigated by mechanical analysis. The results of SEM images and Zetasizer experiments for synthesized nanopowders showed an average size of 100 nm. The nanoparticles distributed as uniform in the chitosan-starch film. The tensile modulus increased for composites containing hydroxyapatite nano-(size particle: 100 nanometer) powders than composites containing micro-(size particle: 100 micrometer) powders. The swelling percentage decreased for samples containing hydroxyapatite nanopowder than the micropowders. These nanocomposites could be applied for hard-tissue engineering.

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“…Biodegradability and nontoxicity, especially mechanical properties, are important factors for scaffolds in hard-tissue engineering [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties of Chitosan-Starch Composite Filled Hydroxyapatite Micro- and Nanopowders

Rezaei‐Tavirani

Biazar

et al. 2011

Journal of Nanomaterials

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“…26),27) For these samples, higher wavenumber regions (40003500 cm ¹1 ), where the OH stretching vibration (about 3570 cm ¹1 ) characteristic to HAp 26) might appear, were difficult to evaluate in detail because of the low resolution of the present measurement method (singlereflection ATR). The TH-XRD patterns for the case of TCPPassemblies adsorbed onto 2-aminoethanethiol-modified substrates showed two peaks at 2ª = 26 and 32°, which were respectively assigned to the 002 diffraction line of HAp and an envelope of the 211, 112, and 300 diffraction line of HAp (PDF#09-0432) (Fig.…”

Section: ¹mentioning

confidence: 99%

Hydroxyapatite deposition on molecular assemblies of a porphyrin derivative under body fluid conditions

Hashizume

Saito

2011

J. Ceram. Soc. Japan

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Biomimetic mineralization is useful to deposit biominerals on various organic scaffolds under mild conditions. This study investigated the use of molecular self-assemblies as scaffolds for hydroxyapatite (HAp) deposition under body fluid conditions. We also evaluated the scaffold assembly structures during mineralization. A porphyrin derivative having carboxylic acid groups (TCPP) was adsorbed from buffer solutions onto solid substrates to form TCPP self-assemblies. The resulting substrates were then immersed in 1.5SBF, a solution having 1.5 times higher inorganic ion concentrations than those of simulated body fluid (SBF). They were then incubated at 36.5°C. The obtained samples' surfaces were examined using various physical characterizations such as scanning electron microscopy, FTIR spectroscopy, and thin-film X-ray diffraction. Furthermore, the samples' surfaces were monitored spectroscopically during HAp deposition, particularly addressing the Soret band peaks of TCPP assemblies that are sensitive to TCPP assembly structures. Results showed that the TCPP assemblies formed on 2-aminoethanethiol-modified solid substrates induced heterogeneous nucleation and growth HAp on their surfaces while maintaining their J-aggregate structures. No marked effect was observed for TCPP assembly structures during HAp deposition when polyelectrolyte thin films were introduced as a soft layer between the TCPP assemblies and solid substrates, which supported the structural rigidity of the TCPP assemblies against HAp formation thereon.

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“…2,4,33,50 The measurement of this ratio can be performed with energy dispersive X-ray analysis (EDXA). 2,33,50,62 Figure 8 shows a typical EDXA spectrum of the prepared HAp nanoparticles. The calculated Ca/P ratios of HAp samples are presented in Table 2.…”

Section: The Ca/p Ratio Of Hap Nanoparticlesmentioning

confidence: 99%

Design of experiments (DOE) for the optimization of hydrothermal synthesis of hydroxyapatite nanoparticles

Sadat‐Shojai¹,

Atai²,

Nodehi³

2011

J. Braz. Chem. Soc.

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O objetivo deste trabalho foi investigar a influência de diversos parâmetros de reação sobre as propriedades de nanopartículas de hidroxiapatita (HAp) preparadas pelo método hidrotérmico. Os dados da literatura descrevem condições experimentais variadas para a síntese hidrotérmica de HAp. Uma abordagem específica foi então utilizada para avaliar os fatores estatisticamente influentes entre aqueles descritos na literatura. O papel de cada parâmetro experimental também foi discutido no contexto da nucleação de partículas e do mecanismo de crescimento de cristais. Dentro das variáveis selecionadas, temperatura e pH foram os fatores que mais afetaram a composição e morfologia da HAp. Além disso, neste estudo, diferentes morfologias variando de nanopartículas cilíndricas do tipo bastonete a esféricas com várias características foram obtidas com sucesso, o que pode ser aplicável na preparação de várias biocerâmicas de HAp.The aim of this work was to investigate the influence of different reaction parameters on the properties of hydroxyapatite (HAp) nanoparticles prepared by the hydrothermal method. The literature data describe widely different experimental conditions for the hydrothermal synthesis of HAp. A specific approach was therefore used to evaluate the statistically influential factors among those described in the literature. The role of each experimental parameter was also discussed within the framework of particle nucleation and crystal growth mechanism. Among the selected variables, temperature and pH were found to be the most significant factors affecting the composition and morphology of the HAp. Moreover, in the present study, different morphologies ranging from rod-like to spherical nanoparticles with various characteristics were successfully obtained, which can be applicable for the preparation of various HAp bioceramics.

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Synthesis and characterization of hydroxyapatite nanoparticles

Cited by 196 publications

References 18 publications

Mechanical Properties of Chitosan-Starch Composite Filled Hydroxyapatite Micro- and Nanopowders

Mechanical Properties of Chitosan-Starch Composite Filled Hydroxyapatite Micro- and Nanopowders

Hydroxyapatite deposition on molecular assemblies of a porphyrin derivative under body fluid conditions

Design of experiments (DOE) for the optimization of hydrothermal synthesis of hydroxyapatite nanoparticles

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