Synthesis and characterization of gold(III) adducts and cyclometallated derivatives with 6-benzyl- and 6-alkyl-2,2′-bipyridines

Abstract

The reaction of a series of 6-substituted-2,2'-bipyridines HL (N2C10H7R, R = CH,Ph, CHMePh, CMe,Ph, CH,Me, CMe, or CH,CMe,) with HAuC1, or Na[AuCl,] has been investigated. Under different experimental conditions, salts [H,L][AuCI,], adducts [Au(HL)Cl,] or cyclometallated derivatives [Au(L)Cl]m] (X = AuCl,, BF4 or PF,) have been isolated. The cyclometallated species arise from direct activation of a C-H bond either of a phenyl or a methyl substituent. The structures of an adduct [Au{N,CloH7(CHMePh)-6}C13] and two metallated species [Au{N,C,oH7(CMe,C,H,)-6}Cl][AuCl,] and [Au{N2CloH7(CMe2CH2)-

Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies

“…9,27 Some gold(III) compounds developed by Cinellu et al [77][78][79][80] are shown to inhibit mitochondrial TrxR2 and to greatly perturb mitochondrial functions. 63 The presumed site of interaction is the selenol moiety present in the active site of the carboxy terminus of the enzyme 63 as well as other cysteine and histidine residues.…”

Synthesis and Characterization of Mononuclear Amidogold(III) Complexes − Crystal Structure of [Au(N2C10H7(CMe2C6H4)‐6](NHC6H3Me2‐2,6)][PF6] − Oxidation of 4‐Methylaniline to Azotoluene

“…A similar distortion has been found in [Au(C,N,N)Cl] ϩ , which differs from the present one only in the substitution of the amido ligand with a chloride. [16] Bond lengths and angles in the present cation can be compared with those found in [Au(C,N,N)Cl] ϩ . Thus, the AuϪN(1) and AuϪC (13) indicates that the trans influence of the amide ligand is stronger than that of the chloride ligand.…”

Novel cycloaurated gold(III) complexes and their effects on styrene polymerization

“…When gold complexes added to the reaction media s-PS was formed ( Fig. 2; Table 1; run nos., [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] After these results were evaluated, series of experiments were conducted at room temperature with different solvents and results. Bulk polymerization was carried out at different catalyst concentrations but conversion did not pass 25% yield.…”

“…Applications of organogold chemistry have been explored by Hashmi [2][3][4]. Organic derivatives of both Au(I) and (III) ions were reported in the review and in more recent papers [5][6][7][8][9][10][11][12][13].…”