Synthesis and characterization of fluorescein isothiocyanate (FITC)-labeled PEO–PCL–PEO triblock copolymers for topical delivery

Cho, Heui Kyoung; Lone, Saifullah; Kim, Dae Duk; Choi, Joon-Ho; Choi, Sung Wook; Cho, Jin Hun; Kim, Jung Hyun; Cheong, In Woo

doi:10.1016/j.polymer.2009.03.032

Cited by 34 publications

(27 citation statements)

References 30 publications

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“…With increasing the content of CL, the crystals become bigger than the polymers with lower lengths of CL. This is mainly ascribed to the competitive crystal formation between PCL and F127 units [42]. As we know, it is easy to form crystalls for CL and thus F127-CLx can form larger spherulites with increasing CL contents, which is also confirmed by the POM image of pure PCL.…”

Section: Characterizations Of F127-clx Block Copolymersupporting

confidence: 52%

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Preparation and characterization of thermosensitive pluronic F127-b-poly(ɛ-caprolactone) mixed micelles

Zhou

Zhang

Chen

et al. 2011

Colloids and Surfaces B: Biointerfaces

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Section: Characterizations Of F127-clx Block Copolymersupporting

confidence: 52%

“…The copolymer concentration could influence the morphology of the micelle solution [42]. Herein, diameter changes of F200 aqueous solutions with different concentrations from 1 mg/mL to 10 mg/mL were tested, as shown in Fig.…”

Section: Themosensitive Behaviorsmentioning

confidence: 99%

Preparation and characterization of thermosensitive pluronic F127-b-poly(ɛ-caprolactone) mixed micelles

Zhou

Zhang

Chen

et al. 2011

Colloids and Surfaces B: Biointerfaces

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“…Among them, amphiphilic and biodegradable block copolymers (e.g. di-and tri-block copolymers based on poly(-caprolactone) (PCL) (Choi et al, 2005;Hyun et al, 2006;Cho et al, 2008Cho et al, , 2009aCho et al, , 2009b, poly(lactic acid) (PLA) (Chognot et al, 2003;You et al, 2004;Choi et al, 2008), and poly(ethylene glycol) (PEG or PEO) (Jeong et al, 1999;Kwon and Okano, 1999;Ge et al, 2002; have been of great interest for the topical delivery of retinol.…”

Section: Introductionmentioning

confidence: 99%

“…Several groups have reported the potential of block copolymers as vehicles for topical delivery (Cho et al, 2009a(Cho et al, , 2009b. However, to the best of our knowledge, few studies discussed the relationship between hydrophile-lipophile characteristic of block copolymers and skin permeation behavior.…”

Section: Introductionmentioning

confidence: 99%

Topical delivery of retinol emulsions co-stabilised by PEO-PCL-PEO triblock copolymers: effect of PCL block length

Cho

Cho²,

Choi

et al. 2012

Journal of Microencapsulation

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This article describes enhanced skin permeation and UV/thermal stability of retinol emulsions by the co-stabilisation of Tween20 and biodegradable poly(ethylene oxide)-block-poly(ε-caprolactone)-block-poly(ethylene oxide) (PEO-PCL-PEO) triblock copolymers having different lengths of hydrophobic PCL block. A triblock copolymer with a longer PCL block has a lower hydrophile-lipophile balance (HLB) value. Commercial Retinol 50C® (BASF Co., Ludwigshafen, Germany) was used as the source of retinol. Ultrasonication of the Retinol 50C® emulsion with the triblock copolymers led to an increase in retinol solubilisation and a decrease in average particle size of the resulting retinol emulsion. These characteristics improved skin permeation of retinol through the stratum corneum of artificial skin and subsequent proliferation of viable epidermis cell. Employment of the triblock copolymer with a longer PCL block increased both UV and thermal stabilization of the retinol. These results suggest that HLB and PCL block length are important factors to enhance the topical delivery of retinol into the skin.

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“…27 33 It was coupled to poly(vinyl alcohol) to make water-soluble pH and temperature sensitive polymer, 34 and was labeled to block copolymer to study skin penetration of biodegradable polymer. 35 Furthermore, fluorescein was attached to polyester backbone for light emitting polymer, 36 and poly(allylamine) for electro potential responsive thin film. 37 In this investigation, SMPU that contained fluorescent dyes grafted to polymer backbone was researched, because this type of fluorescent SMPU was not reported, and could have potential applications in detecting any surrounding change in metal ion concentration, pH, or temperature and to signal the difference by shifting its emission wavelength.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Fluorescent Shape Memory Polyurethanes Grafted with Various Dyes

Chung¹,

Choi²,

Lee³

et al. 2011

Bulletin of the Korean Chemical Society

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Shape memory polyurethane (SMPU), grafted with a fluorescent dye (Rhodamine, Mehylene violet, or Fluorescein) through an allophanate linking, was tested for the fluorescence and the shape recovery effect. The main chain of SMPU was composed of 4,4'-methylenebis(phenylisocyanate) (MDI), poly(tetramethyleneglycol) (PTMG), and 1,4-butanediol (BD), and a fluorescent dye was connected through a second MDI linked to the carbamate moiety of the main chain. Three series of SMPU, differing according to their dye content, were prepared to compare their shape recovery and fluorescence properties. In tensile mechanical property, maximum stress increased up to 350% compared to the linear SMPU, and strain remained above 2000%. Shape recovery went to as high as 97%, and remained almost same after repetitive shape recovery test cycles. Finally, the fluorescence emission of SMPU was demonstrated in the luminescence spectrum and fluorescent light emission pictures. In addition, the response of SMPU to external stimuli such as metal ions was investigated.

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Synthesis and characterization of fluorescein isothiocyanate (FITC)-labeled PEO–PCL–PEO triblock copolymers for topical delivery

Cited by 34 publications

References 30 publications

Preparation and characterization of thermosensitive pluronic F127-b-poly(ɛ-caprolactone) mixed micelles

Preparation and characterization of thermosensitive pluronic F127-b-poly(ɛ-caprolactone) mixed micelles

Topical delivery of retinol emulsions co-stabilised by PEO-PCL-PEO triblock copolymers: effect of PCL block length

Investigation of Fluorescent Shape Memory Polyurethanes Grafted with Various Dyes

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