Synthesis and Characterization of Dinuclear Metal Complexes Stabilized by Tetradentate Schiff Base Ligands

Abstract

<b>Problem statement:</b> The synthesis, spectroscopic properties and theoretical calculations of acetylacetonimine and acetylacetanilidimine Schiff-base ligands, L₁H and L₂H, respectively and their dinuclear complexes of the type [M₂L_nCl₂(H₂O)₂], where n = 1 or 2, M = Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) are described. <b>Approach:</b> The new tetradentate dianion Schiff base ligand which was used as stabilizers for the complexes were prepared by condensation of hydrazine with acetylacetone or acetylacetanilide. The dinuclear complexes of theses ligands were synthesized by treating an ethanolic solution of the prepared ligand with hydrated metal salts in molar ratio of 1:2 (L:M). <b>Results:</b> The ligand and their dinuclear metal complexes were characterized by CHN elemental analysis, FT-IR, UV-Vis, ¹HNMR (for the ligands), conductivity, magnetic susceptibility and theoretical calculation by using MM2 modeling program. <b>Conclusion:</b> The reaction of these ligands in a 1:2 (L:M) afford dinuclear M(II) metal complexes with tetrahedral arrangement around Co(II), Zn(II) and Cd(II) and square planar around Ni(II) and Cu(II)

Binuclear Cu(II) Schiff base complexes as prescursors for the synthesis of CuO nanoparticles: anticancer activity against MCF-7 cell line

“…The two broad bands observed at 591-688 nm and 702-734 nm in the complexes 1 and 2 were attributed to the 2 B 1 g → 2 A 1 g and 2 B 1 g → 2 E g transitions, respectively, suggest a square planar geometry around each Cu(II) ion. [33] This was further confirmed by the magnetic moment value of 1.92B.M . This assignment was in good agreement with the assignments made for the similar copper complexes.…”

Ruthenium(III) Complexes of Heterocyclic Tridentate (ONN) Schiff Base: Synthesis, Characterization and its Biological Properties as an Antiradical and Antiproliferative Agent

“… Antiproliferative measurements of heterocyclic ruthenium(III) complexes graphs [ 2 , 3 , 4 ], parthenolide [D] in A – C representing cell viability charts for the corresponding Ru(III) complexes against the selected cancer cell lines. ( A ) Human renal cancer cell (TK-10); ( B ) Human melanoma cancer cell (UACC-62); ( C ) Human breast cancer cell (MCF-7).…”

“…There have been different reports on the preparation and spectral analysis of various forms of Schiff base ligands, including bi-, tri-, tetra- and polydentate incorporating transition and non-transition metals [ 1 , 2 , 3 ]. Schiff base-transition metal complexes obtained from heterocyclic molecules have received attention from many researchers regarding the development of bioinorganic compounds for biological application [ 4 ].…”

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“…Electronic Absorption Spectral Data: The UV-Vis spectral data of the ligand and its complexes were measured within a 200-800 nm wavelength at room temperature in the DMSO solution. The electronic spectra of the mixed ligand exhibit absorption bands at 296 and 384 nm, which is referred to the aromatic benzene rings ( → *) and imine group (n→ *) respectively 30 .…”