Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells

Kumar, Sathish Sundar Dhilip; Mahesh, Ayyavu; Surianarayanan, M.; Mandal, Asit Baran

doi:10.1016/j.bbagen.2014.01.016

Cited by 82 publications

(45 citation statements)

References 41 publications

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“…Upon co-loading of Cur and Ptx drugs onto the GP cargo, the hydrodynamic average size increased to ≈140 nm. Using the current GP as a delivery vehicle generates substantially smaller particle sizes compared to the reported Cur loaded lipid-polymer nanoparticles with the sizes of 184 nm23.…”

Section: Resultsmentioning

confidence: 88%

Exceedingly Higher co-loading of Curcumin and Paclitaxel onto Polymer-functionalized Reduced Graphene Oxide for Highly Potent Synergistic Anticancer Treatment

Muthoosamy

Abubakar²,

Bai

et al. 2016

Sci Rep

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Metastasis of lung carcinoma to breast and vice versa accounts for one of the vast majority of cancer deaths. Synergistic treatments are proven to be the effective method to inhibit malignant cell proliferation. It is highly advantageous to use the minimum amount of a potent toxic drug, such as paclitaxel (Ptx) in ng/ml together with a natural and safe anticancer drug, curcumin (Cur) to reduce the systemic toxicity. However, both Cur and Ptx suffer from poor bioavailability. Herein, a drug delivery cargo was engineered by functionalizing reduced graphene oxide (G) with an amphiphilic polymer, PF-127 (P) by hydrophobic assembly. The drugs were loaded via pi-pi interactions, resulting in a nano-sized GP-Cur-Ptx of 140 nm. A remarkably high Cur loading of 678 wt.% was achieved, the highest thus far compared to any other Cur nanoformulations. Based on cell proliferation assay, GP-Cur-Ptx is a synergistic treatment (CI < 1) and is highly potent towards lung, A549 (IC50 = 13.24 μg/ml) and breast, MDA-MB-231 (IC50 = 1.450 μg/ml) cancer cells. These positive findings are further confirmed by increased reactive oxygen species, mitochondrial membrane potential depletion and cell apoptosis. The same dose treated on normal MRC-5 cells shows that the system is biocompatible and cancerous cell-specific.

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Section: Resultsmentioning

confidence: 88%

Exceedingly Higher co-loading of Curcumin and Paclitaxel onto Polymer-functionalized Reduced Graphene Oxide for Highly Potent Synergistic Anticancer Treatment

Muthoosamy

Abubakar²,

Bai

et al. 2016

Sci Rep

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show abstract

“…Curcumin is a natural lipophilic polyphenol found in the rhizomes of turmeric (Curcuma longa) (Kumar, Mahesh, Mahadevan, & Mandal, 2014). It has been used as a traditional medicine and as a food pigment in India and China for centuries.…”

Section: Introductionmentioning

confidence: 99%

Core–shell biopolymer nanoparticle delivery systems: Synthesis and characterization of curcumin fortified zein–pectin nanoparticles

et al. 2015

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“…43 Another approach has led to the generation of nanoparticles of curcumin. Nanoparticle curcumin was effective at suppressing the growth of MCF-7 breast cancer cells, 44 and at inhibiting NFκB activity and inducing apoptosis in human pancreatic tumor cell lines. 45 Liposomal curcumin also was shown to be an effective anticancer agent in a pancreatic cancer xenograft model.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Growth Suppression of Renal Carcinoma Cells by Curcumin

Konduri¹,

Bangaru²,

Thanh³

et al. 2015

Journal of Patient-Centered Research and Reviews

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Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells

Cited by 82 publications

References 41 publications

Exceedingly Higher co-loading of Curcumin and Paclitaxel onto Polymer-functionalized Reduced Graphene Oxide for Highly Potent Synergistic Anticancer Treatment

Exceedingly Higher co-loading of Curcumin and Paclitaxel onto Polymer-functionalized Reduced Graphene Oxide for Highly Potent Synergistic Anticancer Treatment

Core–shell biopolymer nanoparticle delivery systems: Synthesis and characterization of curcumin fortified zein–pectin nanoparticles

In Vitro Growth Suppression of Renal Carcinoma Cells by Curcumin

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