Synthesis and characterization of an open-pore toxic-element-free Ti-based bulk metallic glass foam for bio-implant application

Liao, Y.C.; Song, Shuang; Li, T.H.; Li, J.B.; Tsai, P.H.; Jang, J.S.C.; Huang, C.H.; Huang, J.C.; Lin, Che-Hsin; Lin, Yi Hsin; Chen, C.H.

doi:10.1016/j.jmrt.2020.02.079

Cited by 13 publications

(5 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The porosity allowed for bone ingrowth and well anchoring. The research reported by Liao et al [ 165 ] confirmed the results with the porous Ti 42 Zr 40 Si 15 Ta 3 BMG, which also supported the cells’ growth into the porous structure without the distinctive BMG-tissue interface, after implantation in the tibias of the New Zealand white rabbits ( Figure 21 ). No inflammatory reaction was observed 6 months after implantation and the newly formed bone had a density similar to the surrounding bone tissue, indicating the excellent osseo-induction property.…”

Section: Ti-based Metallic Glassessupporting

confidence: 64%

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Biały

Hasiak

Łaszcz

2022

JFB

View full text Add to dashboard Cite

The continuous development of novel materials for biomedical applications is resulting in an increasingly better prognosis for patients. The application of more advanced materials relates to fewer complications and a desirable higher percentage of successful treatments. New, innovative materials being considered for biomedical applications are metallic alloys with an amorphous internal structure called metallic glasses. They are currently in a dynamic phase of development both in terms of formulating new chemical compositions and testing their properties in terms of intended biocompatibility. This review article intends to synthesize the latest research results in the field of biocompatible metallic glasses to create a more coherent picture of these materials. It summarizes and discusses the most recent findings in the areas of mechanical properties, corrosion resistance, in vitro cellular studies, antibacterial properties, and in vivo animal studies. Results are collected mainly for the most popular metallic glasses manufactured as thin films, coatings, and in bulk form. Considered materials include alloys based on zirconium and titanium, as well as new promising ones based on magnesium, tantalum, and palladium. From the properties of the examined metallic glasses, possible areas of application and further research directions to fill existing gaps are proposed.

show abstract

Section: Ti-based Metallic Glassessupporting

confidence: 64%

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Biały

Hasiak

Łaszcz

2022

JFB

View full text Add to dashboard Cite

show abstract

“…Among imaging techniques, either SEM 2,9 or TEM 12,28 are typically used for visualizing pores within the size range of our GF. Also, micro-CT is used occasionally.…”

Section: Resultsmentioning

confidence: 99%

Multi-technique structural characterization of glass foams with complex pore structures obtained through phase separation

Oliveira

Meyerhöfer

Carstens

et al. 2021

Mater. Chem. Front.

View full text Add to dashboard Cite

show abstract

“…Titanium and its alloys, such as commercially pure Ti, Ti–6Al–4V, Ti–6Al–7Nb, and Ti–5Al–2.5Fe, have gained widespread use in dental, trauma, and orthopedic surgery, thanks to their exceptional mechanical properties and acceptable biocompatibility. − However, these materials are not without their limitations, e.g., insufficient long-term wear resistance, the potential release of toxic metallic ions during severe corrosion, stress-shielding effects on bone, and the possibility of provoking proinflammatory responses within the human body. ,, …”

Section: Introductionmentioning

confidence: 99%

“…Sarac et al demonstrated that titanium-based metallic glasses (MGs) outperform the gold-standard Ti–6Al–4V when used as dental implants. , Yet, the development of titanium-based metallic glasses devoid of potentially toxic metals is imperative to mitigate any potential inflammatory reactions within the body . In light of this, titanium-based bulk metallic glasses (BMGs) have emerged as promising implant materials due to their advantageous engineering properties such as low elastic modulus, high strength, toughness, corrosion resistance and, in some cases, even intrinsic antibacterial properties, superior to conventional crystalline Ti-alloys. ,− Consequently, numerous Ti-based BMGs have been reported, exhibiting favorable characteristics compared to traditional crystalline Ti-based alloys. , Nevertheless, many of these BMGs contain elements like Ni, Cu, and/or Be, which are known to be harmful to the human body due to their cytotoxicity. ,− ,− As a result, their inclusion limits the application of Ti-based BMGs in the medical field. Hence, the pursuit of new glass-forming alloys without potentially toxic elements becomes imperative to effectively harness Ti-based metallic glasses for implant materials.…”

Section: Introductionmentioning

confidence: 99%

“… 14 , 19 Nevertheless, many of these BMGs contain elements like Ni, Cu, and/or Be, which are known to be harmful to the human body due to their cytotoxicity. 1 , 3 − 5 , 20 − 22 As a result, their inclusion limits the application of Ti-based BMGs in the medical field. Hence, the pursuit of new glass-forming alloys without potentially toxic elements becomes imperative to effectively harness Ti-based metallic glasses for implant materials.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anticorrosion and Antimicrobial Tannic Acid-Functionalized Ti-Metallic Glass Ribbons for Dental Abutment

Yüce,

Sharifikolouei,

Micusik

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

In this study, a recently reported Ti-based metallic glass (MG), without any toxic element, but with a significant amount of metalloid (Si−Ge−B, 18 atom %) and minor soft element (Sn, 2 atom %), was produced in ribbon form using conventional single-roller melt-spinning. The produced Ti 60 Zr 20 Si 8 Ge 7 B 3 Sn 2 ribbons were investigated by differential scanning calorimetry and X-ray diffraction to confirm their amorphous structure, and their corrosion properties were further investigated by open-circuit potential and cyclic polarization tests. The ribbon's surface was functionalized by tannic acid, a natural plant-based polyphenol, to enhance its performance in terms of corrosion prevention and antimicrobial efficacy. These properties can potentially be exploited in the premucosal parts of dental implants (abutments). The Folin and Ciocalteu test was used for the quantification of tannic acid (TA) grafted on the ribbon surface and of its redox activity. Fluorescent microscopy and ζ-potential measurements were used to confirm the presence of TA on the surfaces of the ribbons. The cytocompatibility evaluation (indirect and direct) of TA-functionalized Ti 60 Zr 20 Si 8 Ge 7 B 3 Sn 2 MG ribbons toward primary human gingival fibroblast demonstrated that no significant differences in cell viability were detected between the functionalized and as-produced (control) MG ribbons. Finally, the antibacterial investigation of TA-functionalized samples against Staphylococcus aureus demonstrated the specimens' antimicrobial properties, shown by scanning electron microscopy images after 24 h, presenting a few single colonies remaining on their surfaces. The thickness of bacterial aggregations (biofilm-like) that were formed on the surface of the as-produced samples reduced from 3.5 to 1.5 μm.

show abstract

Synthesis and characterization of an open-pore toxic-element-free Ti-based bulk metallic glass foam for bio-implant application

Cited by 13 publications

References 32 publications

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Multi-technique structural characterization of glass foams with complex pore structures obtained through phase separation

Anticorrosion and Antimicrobial Tannic Acid-Functionalized Ti-Metallic Glass Ribbons for Dental Abutment

Contact Info

Product

Resources

About