Synthesis and characterization of Al(III) complex with paracetamol

Abstract

The complex of Al (111) with paracetamol have synthesized and characterized using UV–Vis, Infrared spectroscopies and melting point. The ligand has been found to behave as tridentate chelating agents. Paracetamol complex coordinate through the carboxylate oxygen, phenolate oxygen atom, and amine group. The complex solubility was evaluated for several solvents and it was found the compound was more soluble in DMSO. Job’s method of continuous variation suggested 1 : 2 metals to ligand stoichiometry for paracetamol complex

Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials

“…BF-PCL films revealed a burst release during the first hour of immersion followed by a further release of the remaining load up to ~90% in 96 h. However, for the loaded Mg-HHC system, a rather gradual elution was observed over the time, with only 20 and 40% of PAR and CIP loads released after 10 days, respectively. This may be associated with the formation of insoluble chelates between Mg 2+ and Ca 2+ and CIP 0 or PAR 0 (Zwitterionic) in the medium [34][35][36][37], reducing the PAR and CIP release. This is in agreement with the observation of other previous reports where the complexation of different cations with CIP and PAR structures has been shown to reduce bioavailability [38,39].…”