Synthesis and characterization of a novel magnetic molecularly imprinted polymer with incorporated graphene oxide for drug delivery

Hemmati, Khadijeh; Sahraei, Razieh; Ghaemy, Mousa

doi:10.1016/j.polymer.2016.08.074

Cited by 55 publications

(14 citation statements)

References 51 publications

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“…Subsequently, in the presence of functional monomers and crosslinkers, the AA monolayer will direct the selective occurrence of polymerization at the surface of MNPs [ 68 , 77 , 87 ]. This simple approach was rapidly used in other studies as a bullet point to increase drug loading and imprinting yield [ 78 , 88 ].…”

Section: Magnetic Molecularly Imprinted Polymer (Mmip) Preparationmentioning

confidence: 99%

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Sanadgol

Wackerlig

2020

Pharmaceutics

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Cancer therapy is still a huge challenge, as especially chemotherapy shows several drawbacks like low specificity to tumor cells, rapid elimination of drugs, high toxicity and lack of aqueous solubility. The combination of molecular imprinting technology with magnetic nanoparticles provides a new class of smart hybrids, i.e., magnetic molecularly imprinted polymers (MMIPs) to overcome limitations in current cancer therapy. The application of these complexes is gaining more interest in therapy, due to their favorable properties, namely, the ability to be guided and to generate slight hyperthermia with an appropriate external magnetic field, alongside the high selectivity and loading capacity of imprinted polymers toward a template molecule. In cancer therapy, using the MMIPs as smart-drug-delivery robots can be a promising alternative to conventional direct administered chemotherapy, aiming to enhance drug accumulation/penetration into the tumors while fewer side effects on the other organs. Overview: In this review, we state the necessity of further studies to translate the anticancer drug-delivery systems into clinical applications with high efficiency. This work relates to the latest state of MMIPs as smart-drug-delivery systems aiming to be used in chemotherapy. The application of computational modeling toward selecting the optimum imprinting interaction partners is stated. The preparation methods employed in these works are summarized and their attainment in drug-loading capacity, release behavior and cytotoxicity toward cancer cells in the manner of in vitro and in vivo studies are stated. As an essential issue toward the development of a body-friendly system, the biocompatibility and toxicity of the developed drug-delivery systems are discussed. We conclude with the promising perspectives in this emerging field. Areas covered: Last ten years of publications (till June 2020) in magnetic molecularly imprinted polymeric nanoparticles for application as smart-drug-delivery systems in chemotherapy.

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Section: Magnetic Molecularly Imprinted Polymer (Mmip) Preparationmentioning

confidence: 99%

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Sanadgol

Wackerlig

2020

Pharmaceutics

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“…125 The fourth was to coat a thin SiO 2 layer and then introduce vinyl double bond on the surface of the MNPs, followed by coating an organic MIP layer by free radical polymerization. [126][127][128][129][130][131][132][133][134][135][136][137] In order to fix more functional groups, the SiO 2 layer on the surface of MNPs can be designed as a mesoporous silica layer. [126][127][128] In order to make the recognition sites evenly distributed in the shell, the template molecules were fixed on the surface of cores.…”

Section: Surface Modification Of Coresmentioning

confidence: 99%

Designing and controlling the morphology of spherical molecularly imprinted polymers

Tian

Wang

et al. 2020

Mater. Adv.

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“…The sustained and stimuli-responsive release of bioactive compounds has been explored in the development of MIPs as delivery systems for various administration routes (e.g., ocular, dermal, oral, or intravenous) of other therapeutics as well [12,13]. Examples include but are not limited to antipyretics [112], anti-Alzheimer drugs [113] and antipsychotics [114] smoking cessation agents [115], and β-adrenergic antagonists [116].…”

Section: Other Therapeutic Applicationsmentioning

confidence: 99%

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

2019

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Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics' release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers.Polymers 2019, 11, 2085 2 of 33 normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.Polymers 2019, 11, x FOR PEER REVIEW 2 of 34 of both normal and abnormal cells, the severe toxicity and poor bioavailability of conventional drugs, and the multidrug resistance are issues that still need to be addressed by the scientific community.

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Synthesis and characterization of a novel magnetic molecularly imprinted polymer with incorporated graphene oxide for drug delivery

Cited by 55 publications

References 51 publications

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Designing and controlling the morphology of spherical molecularly imprinted polymers

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

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