Synthesis and biological evaluation of N-Alkylamide derivatives as anti-tumor agents

Jiang, Kunxiu; Xing, Yantao; Quan, Qinghua; Sun, Qianqian; Tian, Jingyun; Liu, Cen; Song, Xingzhuo; Wang, Xirui; Liu, Yonggang

doi:10.1016/j.jtcms.2020.09.004

Cited by 3 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…depressus (Ball), such as pellitorine, are antibacterial, insecticidal, anticoagulant, anticancer, and anti-inflammatory agents [ 25 , 26 , 27 ]. Alkylamides ( N -isobutyl-2,4-octadiene-6-monoynamide; (2,4)- N -isobutyl-2,4-undecadiene-8,10-diynamide; N -isobutyl-2,4-heptadiene-6-monoynamide; N -isobutyl-dodeca-2,4,8,10-tetraenamide; and N -isobutyl-2,6,8-datrienamide) were previously confirmed to have activities, such as antioxidant, antimicrobial, anticancer, antithrombotic, antiviral, anti-inflammatory, immunomodulatory, analgesic, antiprotozoal, and antidiabetic activities [ 13 , 28 , 29 , 30 ]. Moreover, propanedioic acid was found to be a monoamine oxidase inhibitor agent with antimycobacterial, antimicrobial, antiviral, anti-HIV, anticancer, antiparasitic, anticonvulsant, antidiabetic, antihypertensive, and anti-hyperlipidemic activities [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus (Ball) Maire: Correlation between Total Phenolic and Flavonoid Contents with Antioxidant and Antimicrobial Activities of Chemically Characterized Extracts

Jawhari

Moussaoui

Bourhia

et al. 2021

Plants

View full text Add to dashboard Cite

In this work, two varieties of Anacyclus pyrethrum (L.) including Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus (Ball) Maire were evaluated for their mineral and chemical compositions, total phenolic and flavonoid contents, and antimicrobial and antioxidant activities using hydroalcoholic extracts from their different parts (leaves, capitula, roots, and seeds). The phytochemical and mineral compositions were carried out using standard methods. The antioxidant activity was determined using the DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azino-bis 3-ethylbenzothiazolin-6-sulfonic acid), and FRAP (ferric reducing antioxidant power) tests. The antimicrobial activity was assayed using the agar diffusion, minimum inhibitory concentration, and minimum bactericidal concentration methods. The results of the chemical analysis showed that both varieties contained interesting mineral and chemical compositions with potentially active compounds; among them, N-isobutyl-2,4-heptadiene-6-monoynamide and cinnamic acid were detected in the Anacyclus pyrethrum var. pyrethrum (L.) only while thiadiazolo [5,4-d] pyrimidin-7-amine and N-isobutyl-2,4-undecadiene-8,10-diynamide compounds were limited to the Anacyclus pyrethrum var. depressus (Ball) Maire. In vitro antioxidant and antimicrobial activities of the two varieties demonstrated that the different parts had prominent antioxidant and antimicrobial properties. The principal component analysis (PCA) showed great similarity in the activity of the leaves, capitula, and seeds of both plants and a high difference in roots. Anacyclus pyrethrum var. pyrethrum roots were characterized by a high content in phenols and flavonoids and better antibacterial activities compared to Anacyclus pyrethrum var. depressus (Ball) Maire roots, which were characterized by better antioxidant activities. From this study, it can be concluded that the two varieties of Anacyclus pyrethrum (L.) showed promising mineral and chemical compositions with antioxidant and antimicrobial properties.

show abstract

Section: Resultsmentioning

confidence: 99%

Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus (Ball) Maire: Correlation between Total Phenolic and Flavonoid Contents with Antioxidant and Antimicrobial Activities of Chemically Characterized Extracts

Jawhari

Moussaoui

Bourhia

et al. 2021

Plants

View full text Add to dashboard Cite

show abstract

“…In the present work, twenty compounds were detected by GC-MS, and among them, sarcosine N -(trifluoroacetyl)-butyl ester, levulinic acid, propanedioic acid, palmitic acid, morphinan-6-one, 4,5 alpha-epoxy-3-hydroxy-17-methyl, 2,4-undecadiene-8,10-diyne- N -tyramide, and isovaleric acid compounds were detected for the first time in this work, according to the best of our knowledge. Some of the compounds identified in the studied extracts of A. pyrethrum (L), such as alkylamides ((2,4)- N -isobutyl-2,4-undecadiene-8,10-diynamide, N -isobutyl-dodeca-2,4,8,10-tetraenamide, N -isobutyl-2,4-octadiene-6-monoynamide, N -isobutyl-2,4-heptadiene-6-monoynamide, and N-isobutyl-2,6,8-datrienamide), were previously confirmed to have activities such as immunomodulatory, antithrombotic, antimicrobial, antiviral, antioxidant, anti-inflammatory, analgesic, anticancer, antidiabetic, and antiprotozoal activities [ 35 , 36 , 37 , 38 ]. Moreover, levulinic acid was found to have anti-inflammatory, anticonvulsant, and antioxidant activities [ 39 , 40 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Anacyclus pyrethrum (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties

et al. 2020

View full text Add to dashboard Cite

Background: Anacyclus pyrethrum (A. pyrethrum) is a wild species belonging to the family Asteraceae, which is used in traditional medicines. Aim of the study: This work was undertaken to study the chemical composition, analgesic, anti-inflammatory, and wound healing properties of hydroalcoholic extracts of different parts (roots, seeds, leaves, and capitula) of A. pyrethrum. Material and Methods: The phytochemical analysis of the studied extracts was conducted by GC-MS. The analgesic activity was evaluated in mice using acetic acid and formaldehyde methods. The anti-inflammatory activity was tested using the inhibitory method of edema induced in rats. The healing activity of the hydroethanolic extracts was explored by excision and incision wound healing models in rats. Results: The phytochemical analysis of the studied plant extracts affirmed the presence of interesting compounds, including some newly detected elements, such as sarcosine, N-(trifluoroacetyl)-butyl ester, levulinic acid, malonic acid, palmitic acid, morphinan-6-One, 4,5.alpha.-epoxy-3-hydroxy-17-methyl, 2,4-undecadiene-8,10-diyne-N-tyramide, and isovaleric acid. The extracts of different parts (roots, seeds, leaves, and capitula) exhibited promising anti-inflammatory, analgesic, and wound healing effects, with percentages of inhibition up to 98%, 94%, and 100%, respectively. Conclusion: This study might contribute towards the well-being of society as it provides evidence on the potential analgesic, anti-inflammatory, and wound healing properties of A. pyrethrum.

show abstract

Effect fraction of Bletilla striata (Thunb.) Reichb.f. alleviates LPS-induced acute lung injury by inhibiting p47 /NOX2 and promoting the Nrf2/HO-1 signaling pathway

Jiang,

Hua,

Pan

et al. 2024

Phytomedicine

View full text Add to dashboard Cite

Synthesis and biological evaluation of N-Alkylamide derivatives as anti-tumor agents

Cited by 3 publications

References 38 publications

Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus (Ball) Maire: Correlation between Total Phenolic and Flavonoid Contents with Antioxidant and Antimicrobial Activities of Chemically Characterized Extracts

Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus (Ball) Maire: Correlation between Total Phenolic and Flavonoid Contents with Antioxidant and Antimicrobial Activities of Chemically Characterized Extracts

Anacyclus pyrethrum (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing Properties

Effect fraction of Bletilla striata (Thunb.) Reichb.f. alleviates LPS-induced acute lung injury by inhibiting p47 /NOX2 and promoting the Nrf2/HO-1 signaling pathway

Contact Info

Product

Resources

About