Synthesis and biological evaluation of new naphthalimide–thiourea derivatives as potent antimicrobial agents active against multidrug-resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i>

Rana, Preeti; Parupalli, Ramulu; Akhir, Abdul; Saxena, Deepanshi; Maitra, Rahul; Imran, Mohmmad; Malik, Pradip; Mahammad Ghouse, Shaik; Joshi, Swanand Vinayak; Srikanth, Danaboina; Madhavi, Y. V.; Dasgupta, Arunava; Chopra, Sidharth; Nanduri, Srinivas

doi:10.1039/d4md00062e

RSC Med. Chem.

2024

DOI: 10.1039/d4md00062e

|View full text |Cite

Synthesis and biological evaluation of new naphthalimide–thiourea derivatives as potent antimicrobial agents active against multidrug-resistant Staphylococcus aureus and Mycobacterium tuberculosis

Preeti Rana,

Ramulu Parupalli,

Abdul Akhir

et al.

Abstract: Novel series of naphthalimide thiourea derivatives were synthesised and evaluated against bacterial pathogen panel and mycobacterial pathogen panel.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery

Ruan,

Xie,

Wang

et al. 2024

Molecules

View full text Add to dashboard Cite

Naphthylimides play a pivotal role as aromatic heterocyclic compounds, serving as the foundational structures for numerous pharmacologically significant drugs. These drugs encompass antibacterial, antifungal, anticancer, antimalarial, antiviral, anti-inflammatory, antithrombotic, and antiprotozoal agents. The planar and heteroaromatic characteristics of naphthylimides grant them a strong ability to intercalate into DNA. This intercalation property renders naphthylimide derivatives highly valuable for various biological activities. The advantageous pharmacological activity and ease of synthesis associated with naphthylimides and their derivatives provide significant benefits in the design and development of new compounds within this class. Currently, only a few such molecules are undergoing preclinical and clinical evaluations. In this paper, we have compiled the literature on naphthylimides reported by researchers from 2006 to 2024. Our focus lies on exploring the pharmacological activities of their analogues from a drug development and discovery perspective, while examining their structure–activity relationship and mechanisms of action.

show abstract

An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery

Ruan,

Xie,

Wang

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Synthesis and biological evaluation of new naphthalimide–thiourea derivatives as potent antimicrobial agents active against multidrug-resistant Staphylococcus aureus and Mycobacterium tuberculosis

Abstract: Novel series of naphthalimide thiourea derivatives were synthesised and evaluated against bacterial pathogen panel and mycobacterial pathogen panel.

Cited by 1 publication

References 37 publications

An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery

An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery

Contact Info

Product

Resources

About