Synthesis and biological activity of some heterocyclic compounds containing benzimidazole and beta-lactam moiety

Ansari, Khursheed; Lal, Chhagan

doi:10.1007/s12039-009-0114-8

Cited by 42 publications

(27 citation statements)

References 29 publications

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“…The effectiveness of the benzimidazole and triazole moieties towards various microbes prompted the synthesis of some new benzimidazole derivatives bearing the triazole nucleus and the screening of their potential biological activities. In continuation of studies on biologically active benzimidazole derivatives, [23][24][25] the results of the synthesis of some new benzimidazole derivatives having a triazole nucleus are reported herein.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological activity of some triazole-bearing benzimidazole derivatives

Ansari

Lal

Khitoliya

2011

JSCS

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A number of N'-(arylmethylidene)-2-(2-methyl-1H-benzimidazol--1-yl)acetohydrazide and 4-aryl-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]--4H-1,2,4-triazole-3-thiol derivatives were synthesized by incorporating various aromatic and heterocyclic substituents on 2-methyl-1H-benzimidazole. The structures of all the synthesized compounds were elucidated based on their elemental analyses and spectral data. The in vitro activities of these compounds against bacteria and fungi were evaluated by the disc diffusion and the minimum inhibitory concentration (MIC) methods. Some of the synthesized derivatives were found to be as active as kanamycin (standard drug).

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Section: Introductionmentioning

confidence: 99%

Synthesis and biological activity of some triazole-bearing benzimidazole derivatives

Ansari

Lal

Khitoliya

2011

JSCS

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“…Heterocyclic compounds have occupied a unique place in the chemistry, and these compounds displayed a wide range of biological activities, such as antibacterial and antifungal activities [1][2][3][4][5][6]. Further, the treatment of infectious diseases is illnesses caused still remains an important and challenging problem for researchers due to their combination factors increase the number of multidrug-resistant in microbial pathogens developed.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis of Biologically Active Heterocycles Containing Indol- Thiazolyl- Thiazolidinone Derivatives

Walmik

Naraboli

Swathi

et al. 2018

Asian J Pharm Clin Res

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Objective: The present study envisage a novel series of thiazole, indole and thiazolidine derivatives, namely, N- 5,6,7,thiazole-2-amine (4a-c), 2-(5-substituted-2-phenyl-1H-indol-3-yl)-3- (4,5,6,7-trimethylbenzo[d]thiazol-2-yl)-thiazolidin-4-one (5a-c) and 5-benzylidine-2-(5-substituted-2phenyl-1H-indol-3yl)-3- (4,5,6,7-tetrahydro-5,5,7-trimethylbenzo[d]thiazol-2-yl) thiazolidin-4-one (6a-c).Methods: All the newly synthesized compounds were characterized by infrared, 1 H, 13 C nuclear magnetic resonance and mass spectral data and elemental analysis and evaluated for in vitro antimicrobial activity.Results: Novel compounds N- 5,6,7,thiazole-2-amine (4a-c), 2-(5-substituted-2-phenyl-1H-indol-3-yl)-3-(4,5,6,7-trimethylbenzo[d]thiazol-2-yl)-thiazolidin-4-one (5a-c) and 5-benzylidine-2-(5-substituted2phenyl-1H-indol-3yl)-3- (4,5,6,7-tetrahydro-5,5,7-trimethyl benzo[d]thiazol-2-yl)thiazolidin-4-one (6a-c) have been made and characterized using spectral and analytical data. The results of antibacterial and antifungal activities showed that some of the synthesized compounds exhibited promising activities. Conclusion:All the newly synthesized compounds were carried out by the broth microdilution method (NCCLS. 2002) in a DMF concentration of 500, 250, 125, and 62.5 µg/ml. Gentamycin and fluconazole are used as reference standards for antibacterial and antifungal activity, respectively. The final results revealed that compounds 4b, 5b, and 6b exhibited potent antimicrobial activity when compared to the standard drugs.

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“…There has been significant increase in the development of disperse dyes due to increasing use of polyester fibers and their blend [1-3], 2-amino thiazole derivatives [4][5][6][7][8] have been utilized as heterocyclic components since long for many disperse dyes. The synthesis of thiazole, 2-amino-4-phenyl thiazole and their derivatives has got significant importance because a large number of natural products and drugs comprise of this heterocyclic moiety [9][10][11]. It was our main objective to synthesize monoazo disperse dyes based on 2-chloro-N-(4-nitrophenyl)acetamide [12,13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of monoazo disperse dyes, their dyeing performance on polyester fibers and antimicrobial activity

Patel¹,

Patel²,

Malik³

2014

IOSRJAC

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amino)acetamide derivatives has been synthesized in the current study using different diazotized aryl amines. These were characterized using elemental analysis, 1 H NMR and IR spectra. Their dyeing performance on polyester fiber was assessed and fastness properties of these dyes were evaluated by applying them to polyester fiber. These dyes showed moderate anti-bacterial and anti-fungal activities.

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Synthesis and biological activity of some heterocyclic compounds containing benzimidazole and beta-lactam moiety

Cited by 42 publications

References 29 publications

Synthesis and biological activity of some triazole-bearing benzimidazole derivatives

Synthesis and biological activity of some triazole-bearing benzimidazole derivatives

Design, Synthesis of Biologically Active Heterocycles Containing Indol- Thiazolyl- Thiazolidinone Derivatives

Synthesis of monoazo disperse dyes, their dyeing performance on polyester fibers and antimicrobial activity

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