Synthesis and biological activities of bicyclic pyridines integrated steroid hybrid

Synthesis, in silico ADMET prediction analysis, and pharmacological evaluation of sulfonamide derivatives tethered with pyrazole or pyridine as anti-diabetic and anti-Alzheimer's agents

“… The biological effects of pyrazole, pyridine, and sulfonamide derivatives. Nitrogenous compounds with multiple biological activities, such as antioxidant, anti-diabetic, anti-Alzheimer, and anti-arthritic agents ( Zahoor et al, 2023 , Hammouda et al, 2023 , Zhang et al, 2024 , Abdel-Aziz et al, 2015 , Hashem et al, 2023 ). In addition to our previous studies that highlight the development of various compounds and evaluation of their biological effects as potential drug candidates ( Mukhtar et al, 2021 , Hassan et al, 2015 , Morsy et al, 2021 ).…”

“…Nitrogenous compounds with multiple biological activities, such as antioxidant, anti-diabetic, anti-Alzheimer, and anti-arthritic agents ( Zahoor et al, 2023 , Hammouda et al, 2023 , Zhang et al, 2024 , Abdel-Aziz et al, 2015 , Hashem et al, 2023 ).…”

Design, synthesis, biological and computational screening of novel pyridine-based thiadiazole derivatives as prospective anti-inflammatory agents

“…Due to its excellent physico-chemical and biological profiles pyridine template serves as the essential moiety in many drugs like metyrapone, piroxicam (anti-inflammatory), phenazopyridine (urinary tract analgesic), omeprazole, pantoprazole (antiulcer), Tacrine(anti-alzheimer's), isoniazid (antitubercular), nicorandil (vasodilator), and nikethamide (respiratory stimulant) ( Fig. 1 ) [ [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] ].

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Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids

“…A number of excellent reviews on synthetic strategies directed towards the synthesis of heterosteroids have emerged in recent years [6,7]. Some of them focused on heterocycles [8], including fused-thiazoles [9], pyrazolines [10], bicyclic pyridines [11], and pyrimidines [12]. Other highlight the advances of steroid D-ring modification [13,14] or advances in the synthesis of steroidal conjugates and dimers [15][16][17].…”