Eur. J. Chem. volume 1, issue 4, P297-301 2010 DOI: 10.5155/eurjchem.1.4.297-301.20
Alahari Janardhan Rao, Valasani Koteswara Rao, Pasupuleti Visweswara Rao, Chamarthi Naga Raju, Sunil Kumar Ghosh
Abstract:

KEYWORDSNovel phosphorylated derivatives of stavudine were synthesized by the reaction of bis(2chloroethyl)phosphoramidic dichloride/4-nitrophenyl phosphorodichloridate with various cyclic amines and amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the corresponding monochloride intermediates 2a-l. Further reaction of the intermediates 2a-l with stavudine in tetrahydrofuran and pyridine in the presence of triethylamine formed the title compounds 4a-l. Their structures were…

x
Citation Types
0
1
0
Paper Sections
0
0
0
0
0
Article Types
0
0
0
0