volume 1, issue 4, P297-301 2010
DOI: 10.5155/eurjchem.1.4.297-301.20
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Abstract: KEYWORDSNovel phosphorylated derivatives of stavudine were synthesized by the reaction of bis(2chloroethyl)phosphoramidic dichloride/4-nitrophenyl phosphorodichloridate with various cyclic amines and amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the corresponding monochloride intermediates 2a-l. Further reaction of the intermediates 2a-l with stavudine in tetrahydrofuran and pyridine in the presence of triethylamine formed the title compounds 4a-l. Their structures were cha…

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