Synthesis and binding properties of a noncovalent molecularly imprinted testosterone-specific polymer

Benzylfentanyl as a Surrogate Template for Fentanyl-Selective Imprinted Polymers

“…Two separate columns were packed with a slurry of differently sized MIPs and evaluated using a mobile phase system consisting of MeCN/H 2 O, 99.9/0.1, respectively. The results shown in Table 1 indicate that the 25–37 µm particle sizes produced better IF values compared to the particle size range 11–25 µm, which correlates well with the findings of previous studies [ 26 , 27 ].…”

“…Two separate columns were packed with a slurry of differently sized MIPs and evaluated using a mobile phase system consisting of MeCN/H 2 O, 99.9/0.1, respectively. The results shown in Table 1 indicate that the 25-37 µm particle sizes produced better IF values compared to the particle size range 11-25 µm, which correlates well with the findings of previous studies [26,27]. A priori, it could be envisaged that the smaller particles should provide a better IF due to shorter distances of path length diffusion, resulting in quicker mass transfer kinetics of substrates, increased surface accessibility, and better access to binding sites buried internally in the particles.…”

Tailored binding and transport parameters of molecularly imprinted films via macromolecular structure: The rational design of recognitive polymers

“…For example, the association constant for the 90% crosslinked poly(MAA‐ co ‐EGDMA) recognitive network was equal to (1.3 ± 0.1) × 10 4 M −1 and decreased approximately fourfold to (0.30 ± 0.02) × 10 4 M −1 for the 50% crosslinked network. Also, the association constant for the 77% crosslinking poly‐(MAA‐ co ‐EGDMA) recognitive network ( K a = (1.20 ± 0.07) × 10 4 M −1 ) is in experimental agreement with a literature value5 ( K a = 1.10 × 10 4 M −1 ). Comparing the 77% crosslinked polymers, the poly(MAA‐ co ‐PEG200DMA) recognitive network had an association constant of (0.20 ± 0.05) × 10 4 M −1 which was a sixfold decrease compared to the poly(MAA‐ co ‐EGDMA) recognitive network ( K a = (1.20 ± 0.07) × 10 4 M −1 ).…”

Improved Molecular Imprinting Based on Colloidal Particles Made from Miniemulsion: A Case Study on Testosterone and Its Structural Analogues

“…At this C f , the imprint factors obtained were 1.6, 2.2, and 1.2 for pH 4, 7, and 10, respectively. A similar IF has been reported for testosterone templated MAA/EGDMA MIPs using chloroform as a porogen but ACN for the rebinding studies . It is important to note that a strict comparison of the performance of the MIPs is difficult, as the solvent choice plays a crucial role in binding experiments.…”