Synthesis and aqueous phase behavior of 1-glyceryl monooleyl ether

Barauskas, Justas; Švedaitė, Irena; Butkus, Eugenijus; Razumas, Valdemaras; Larsson, Kåre; Tiberg, Fredrik

doi:10.1016/j.colsurfb.2004.11.008

Cited by 27 publications

(31 citation statements)

References 16 publications

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“…lipases due to lack of ester bond in the molecule [15][16][17][18]. For monoolein, the Pn3m phase formed at hydration over 20%, is stable in the presence of excess of water which is important when the cubic phase is considered as an electrode modifying material [11,19].…”

Section: Introductionmentioning

confidence: 99%

Catalytic activity of oxidases hosted in lipidic cubic phases on electrodes

Nazaruk

Bilewicz

2007

Bioelectrochemistry

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Section: Introductionmentioning

confidence: 99%

Catalytic activity of oxidases hosted in lipidic cubic phases on electrodes

Nazaruk

Bilewicz

2007

Bioelectrochemistry

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“…The phase behaviour of the fully hydrated PHYT system has been shown previously 18,19 and reproduced here for comparison to the new systems which exhibited slightly reduced phase transition temperatures on addition of GNR to the matrix. This phase transition temperature has been reported to be 63 1C, 40 but was not observed in this system and is attributed to the use of a different source of material. 52,53 The lattice parameters of the SA matrix were unaffected by the presence of GNR, and the H 2 to L 2 phase transition of SA was not observed in the temperature range investigated.…”

Section: Equilibrium Behaviour Of Bulk Gnr-lipid Hybrid Nanomaterialsmentioning

confidence: 47%

“…40 As ME displays different phase transitions to these matrices that form inverse nanostructures, it will be considered separately. The GMO and SA systems had similar phase behaviour to PHYT at higher temperatures, where GMO exhibited the V 2 to H 2 to L 2 phase transitions and SA is reported to undergo the H 2 to L 2 phase transition.…”

Section: Phyt Gmo and Samentioning

confidence: 99%

“…31,32 Due to their efficient photoconversion and biocompatibility, gold nanoparticles have been proposed for use in pharmaceutical applications such as thermal ablative therapy, 33 diagnostics 34 and stimuli-responsive drug delivery. Specifically, the dynamic photoresponsive transition behaviour on irradiation of GNR-containing mesophases in excess water was studied for the bicontinuous cubic phase formed by glycerol monooleate (GMO), 38,39 the hexagonal phase formed using selachyl alcohol (SA) 40 and the lamellar phase formed by monoelaidin (ME). 37 This work examines the influence of the physicochemical properties and phase structure of the matrix and the energetics of their phase transitions on the photothermal response of liquid crystalline systems.…”

Section: Introductionmentioning

confidence: 99%

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Understanding the photothermal heating effect in non-lamellar liquid crystalline systems, and the design of new mixed lipid systems for photothermal on-demand drug delivery

Fong

Hanley

Thierry

et al. 2014

Phys. Chem. Chem. Phys.

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Lipid-based liquid crystalline systems are showing potential as stimuli-responsive nanomaterials, and NIR-responsive gold nanoparticles have been demonstrated to provide control of transitions in non-lamellar phases. In this study, we focus on a deeper understanding of the photothermal response of both lamellar and non-lamellar phases, and new systems formed by alternative lipid systems not previously reported, by linking the photothermal heating to the bulk thermal properties of the materials. Dynamic photothermal studies were performed using NIR laser irradiation and monitoring the structural response using time resolved small angle X-ray scattering for the bulk phases and hexosomes. In addition, cryoFESEM and cryoTEM were used to visualise and assess the effect of GNR incorporation into hexagonal phase nanostructures. The ability of the systems to respond to photothermal heating was correlated with the thermal phase behaviour and heat capacities of the different structures. Access to alternative phase transitions in these systems and understanding the likely photothermal response will facilitate different modes of application of these hybrid nanomaterials for on-demand drug delivery applications.

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“…1. 19,20) It was reported that GME formed a reverse hexagonal phase 18) and a cubic phase in a water-propylene glycol mixture. 21) However, few results have been reported on the use of GME-based LLC systems for transdermal delivery.…”

mentioning

confidence: 99%

Glyceryl Monooleyl Ether-Based Liquid Crystalline Nanoparticles as a Transdermal Delivery System of Flurbiprofen: Characterization and <i>in Vitro</i> Transport

et al. 2015

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Liquid crystalline nanoparticles (LCNs) were prepared using glyceryl monooleyl ether (GME) by the modified film rehydration method. Hydrogenated lecithin (HL), 1,3-butylene glycol (1,3-BG), and Poloxamer 407 were used as additives. The prepared LCN formulations were evaluated based on particle size, smallangle X-ray diffraction (SAXS) analysis, 1 H-and 19F-NMR spectra, and in vitro skin permeation across Yucatan micropig skin. The composition (weight percent) of the LCN formulations were GME-HL-1,3-BG (4 : 1 : 15), 4% GME-based LCN and GME-HL-1,3-BG (8 : 1 : 15), 8% GME-based LCN and their mean particle sizes were 130-175 nm. Flurbiprofen 5 and 10 mg was loaded into 4% GME-based LCN and 8% GMEbased LCN systems, respectively. The results of SAXS and NMR suggested that both flurbiprofen-loaded formulations consist of particles with reverse type hexagonal phase (formation of hexosome) and flurbiprofen molecules were localized in the lipid domain through interaction of flurbiprofen with the lipid components. Flurbiprofen transport from the LCN systems across the Yucatan micropig skin was increased compared to flurbiprofen in citric buffer (pH 3.0). The 8% GME-based LCN systems was superior to the 4% GME-based LCN for flurbiprofen transport. Since the internal hexagonal phase in the 8% GME-based LCN systems had a higher degree of order compared to the 4% GME-based LCN in SAXS patterns, the 8% GME-based LCN system had a larger surface area, which might influence flurbiprofen permeation. These results indicated that the GME-based LCN system is effective in improving the skin permeation of flurbiprofen across the skin.Key words lyotropic liquid crystal; liquid crystalline nanoparticle; hexosome; skin permeation; flurbiprofen; NMR Under some circumstances, transdermal delivery may be superior to other routes of delivery due to advantages such as avoidance of first pass elimination and a lack of invasiveness. However, relatively few transdermal drugs have been commercialized owing to the efficient barrier function of the stratum corneum, which is located on the outer layer of the skin. To overcome the barrier function of the stratum corneum, several physical and chemical methods have been developed. 1)Recently, lyotropic liquid crystal (LLC) systems have been developed as a chemical method to overcome the stratum corneum barrier.2,3) LLCs are usually composed of amphiphilic molecules and solvents that can form a variety of structures, including lamellar (L α ), hexagonal (normal, or reverse) and inverted cubic (bicontinuous and micellar) structures. 4) Among these LLC systems, some of liquid crystal structures form a liquid crystalline nanoparticles (LCNs) by dispersing in an aqueous environment and the LCNs of reverse hexagonal phase and bicontinuous cubic phase are called "hexosomes (H II )" and "cubosomes," respectively. 3,5) Glycerol monoolate (GMO) has been widely studied as an additive to form LLCs and their LCNs.6,7) Effect of the additives such as block copolymer formation and electrostatic interaction were also i...

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Synthesis and aqueous phase behavior of 1-glyceryl monooleyl ether

Cited by 27 publications

References 16 publications

Catalytic activity of oxidases hosted in lipidic cubic phases on electrodes

Catalytic activity of oxidases hosted in lipidic cubic phases on electrodes

Understanding the photothermal heating effect in non-lamellar liquid crystalline systems, and the design of new mixed lipid systems for photothermal on-demand drug delivery

Glyceryl Monooleyl Ether-Based Liquid Crystalline Nanoparticles as a Transdermal Delivery System of Flurbiprofen: Characterization and <i>in Vitro</i> Transport

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