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“…[51][52][53] Tweleve compounds were cytotoxic with IC 50 values ranging from 2 to 50 µM and are presented in this report (Table 7).…”
Section: Consensus Modelmentioning
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“…[51][52][53] Tweleve compounds were cytotoxic with IC 50 values ranging from 2 to 50 µM and are presented in this report (Table 7).…”
Section: Consensus Modelmentioning
“…Previously, pyrrolopyrimidine core-containing compounds were reported to inhibit HER tyrosine kinase activity [53,54]. Structures and HER2 tyrosine kinase inhibitory activities of some representative compounds are shown in Figure 12 and Table 7 [122].…”
Section: Pyrrolopyrimidine-based Her2 Tyrosine Kinase Inhibitorsmentioning
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“…Taking this background into account and considering the biologic and antitumor activities of quinazoline derivatives [25][26][27][28][29], the purpose of the present work was to study the cytotoxicity of modified MWCNTs on a human noncancerous cell line (HEK293) and a cancerous one (SKBR3). Our study indicates that MWCNT-quin is highly toxic to cancer cells, and this effect is highly significant compared to its effect on noncancerous cell samples.…”
Section: Statistical Analysesmentioning
“…Quinazoline compounds are widely used in agrochemicals as plant virucides [3], antifungal agents [4] and herbicides [5]. According to recent data, quinazoline nucleus has attracted the attention of medicinal chemists due to its well known anticancer activity, and many substituted quinazoline derivatives have recently earned great interest in chemotherapy as antitumor drugs [6,7]. In order to find potential new plant fungicides and anticancer agents, we had designed and synthesized a series of N-aryl-4-aminoquinazoline compounds, among which some compounds were found to possess moderate bioactivity [8].…”
Section: Introductionmentioning