Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

Abstract

A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a-m) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported.

Selective Radical N−H Activation: the Unprecedented Harnessing of Formamide with S8 for N−S−N Bonds Construction

“…Typically, Wang's group did continuous insecticidal studies of this structure unit, laying a good foundation of its biological applications. To date, chemicals containing N−S−N structural unit have proved its fundamental activities in insecticidal, [1] antibacterial, [2a] anti‐inflammatory, [2b] blood pressure lowering [2c] and antifungal [1] usages (Figure 1).…”