Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo[3,2-a]pyrimidines

Sulfonamide Derivatives of 2-Amino-1-phenylethane as Suitable Cholinesterase Inhibitors

“…These were also employed for the treatment of various infections [1]; as antimicrobial, antithyroid, antitumor and antimalarial agents [2]; as inhibitor of carbonic anhydrase [2]; for the treatment of diabetes [3], HIV/AIDS [4] and bacterial infections in the animals [5]. Sulfonamides inhibit the formation of folic acid necessary for bacterial growth by competing with p-aminobenzoic acid for dihydropteroate synthase enzyme and ultimately inhibit the synthesis of purine and DNA [6].…”

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“…[9,10] Sulfonamides represent an important class of medically important compound, which is present in a number of biologically active molecules. In addition, sulfonamide derivatives are extensively used as antitumor, [11,12] antiviral, [13] antimalarial, [14,15] anti-inflammatory, [16] anticancer, [17] anti-carbonic anhydrase, [18] antidiabetic agents, [19] and in Alzheimer's diseases. [20] Computer-aided structure-based rational drug designing have the potential not only of speeding up the drug discovery process thus reducing the costs, but also of changing the way drugs are designed.…”

Synthesis, Characterization and Biological Screening of Various N-Substituted Derivatives of Sulfonamides

“…Sulfonamides are considered as an important group of drugs which are used widely as antimicrobial, high ceiling diuretics, ant thyroid and anti-inflammatory agents [2]. The mechanism through which sulfonamides perform its function is to inhibit the conversion of p-amino benzoic acid, thus creating hurdle in utilization of p-amino benzoic acid for bacteria in folic acid synthesis which leads to formation of purine and DNA [3].…”