Synthesis and antitumor activity of optically active thiourea and their 2-aminobenzothiazole derivatives: A novel class of anticancer agents

Manjula, S.; Noolvi, N. Malleshappa; Parihar, K. Vipan; Reddy, S.A. Manohara; Ramani, Vijay; Gadad, Andanappa K.; Singh, Gurdial; Kutty, N. Gopalan; Rao, C. Mallikarjuna

doi:10.1016/j.ejmech.2008.12.002

Cited by 124 publications

(50 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies have shown that thioureas have a broad spectrum of biological effects profile including antiviral (3), antitubercular (4,5), antibacterial (6), antifungal (7), antimycobacterial (8), anti-inflammatory (9), anticancer (10), antitumor (11) and antimalarial (12) activity.…”

Section: Introductionmentioning

confidence: 99%

Tiyoüreler, açiltiyoüreler ve 4-tiyazolidinonların sentezi, karakterizasyonu ve antikanser ve antiviral etkilerinin değerlendirilmesi

Kulabaş¹,

Özakpınar²,

Özsavcı³

et al. 2017

Marmara Pharmaceutical Journal

View full text Add to dashboard Cite

In this study, thiourea derivatives [1][2][3][4] were synthesized by using 2-amino-4-substituted pyridine compounds and these compounds have been used as the starting materials for synthesis of 2-imino-1,3-thiazolidin-4-one ring [5,6]. Two different procedures for 4-thiazolidinone ring closure and synthesis method were optimized. The synthesized compounds were identified by the help of elemental analysis, IR, 1 H-NMR, 13 C-NMR and mass spectral data while the purities of them were proved with TLC. Synthesized compounds were evaluated for their antiviral and anticancer activity. Antiviral activity against Murine norovirus, Yellow fever, Enterovirus and Chikungunya strains of the test compounds were investigated and EC 50 values of these compounds were determined higher than 0,3 µM. Cytotoxicity of test compounds was examined on NIH3T3 cell line. When the anticancer activity of test compounds was examined against PC-3, A549, HeLa, HT-29, MCF-7, SJSA1 and K562 cell lines, the percent proliferation values of these compounds were observed over 61% for all cell lines.

show abstract

Section: Introductionmentioning

confidence: 99%

Tiyoüreler, açiltiyoüreler ve 4-tiyazolidinonların sentezi, karakterizasyonu ve antikanser ve antiviral etkilerinin değerlendirilmesi

Kulabaş¹,

Özakpınar²,

Özsavcı³

et al. 2017

Marmara Pharmaceutical Journal

View full text Add to dashboard Cite

show abstract

“…The bond lengths and angles are all present in the expected 34 range. The molecular structure of complex (2) shows that it exists as dimer form in asymmetric unit (Figure 3). Data collection and refinement of complex (2) are listed in Table 7 (supplementary material).…”

Section: Molecular Structure Of Nickel(ii) (2) and Copper(ii) (3) Commentioning

confidence: 99%

“…The precipitates were dissolved in a mixture of ethanol and dichloromethane (1:1) and a clear solution was kept in a refrigerator for one week. Suitable pink and green crystals for X-ray studies were obtained for complexes (2) and (3). The same method was used for the preparation of all other complexes.…”

Section: Synthesis Of N-(dipropylcarbamothioyl)thiophene-2-carboxamidmentioning

confidence: 99%

“…Gold drugs, myocrisin and auranofin are used for the treatment of rheumatoid arthritis. Thiourea (carboxamide) and its derivatives display a wide range of bioactivity [1][2][3][4] . Studies have indicated that thioureas show even a strong antifungal activity comparable to the commonly used antifungal, ketoconazole 5 .…”

Section: Introductionmentioning

confidence: 99%

“…Some metals have been used as drugs to treat various diseases and conditions. Platinum compounds, cisplatin (cis-[Pt(NH 3 ) 2 Cl 2 ]), carboplatin and oxaliplatin are among the most widely used cancer therapeutic agents. Gold drugs, myocrisin and auranofin are used for the treatment of rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity

Hanif

Chohan

Winum

et al. 2013

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

A series of three bioactive thiourea (carboxamide) derivatives, N-(dipropylcarbamothioyl)-and their cobalt(II), copper(II), nickel(II) and zinc(II) complexes (1)- (12) have been synthesized and characterized by their IR, 1 H-NMR spectroscopy, mass spectrometry and elemental analysis data. The Crystal structure of one of the ligand, N-(dipropylcarbamothioyl)thiophene-2-carboxamide (L 1 ) and its nickel(II) and copper(II) complexes were determined from single crystal X-ray diffraction data. All the ligands and metal(II) complexes have been subjected to in vitro antibacterial and antifungal activity against six bacterial species (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and for antifungal activity against six fungal strains (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata). The in vitro antibacterial and antifungal bioactivity data showed the metal(II) complexes to be more potent than the parent ligands against one or more bacterial and fungal strains.

show abstract

Synthesis and structural characterization of new bioactive ligands and their Bi(III) derivatives

Raheel

Imtiaz‐ud‐Din

Andleeb

et al. 2016

Applied Organom Chemis

View full text Add to dashboard Cite

Five new carboxylic acid precursors bearing thiourea group and their corresponding bismuth(III) complexes were synthesized and characterized using CHNS and inductively coupled plasma analyses and infrared and NMR ( 1 H, 13 C) spectroscopies. Single-crystal X-ray diffraction analysis was also carried out for one of the precursors. The behaviour of the compounds was bioassayed for antibacterial, antifungal, antioxidant and enzyme (lipoxygenase, α-glycosidase and anti-urease) inhibition activities. It is concluded that the interaction of the compounds with bismuth enhances both the antimicrobial and enzyme inhibition activities. The synthesized compounds may prove to be good therapeutic agents.

show abstract

Synthesis and antitumor activity of optically active thiourea and their 2-aminobenzothiazole derivatives: A novel class of anticancer agents

Cited by 124 publications

References 25 publications

Tiyoüreler, açiltiyoüreler ve 4-tiyazolidinonların sentezi, karakterizasyonu ve antikanser ve antiviral etkilerinin değerlendirilmesi

Tiyoüreler, açiltiyoüreler ve 4-tiyazolidinonların sentezi, karakterizasyonu ve antikanser ve antiviral etkilerinin değerlendirilmesi

Metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity

Synthesis and structural characterization of new bioactive ligands and their Bi(III) derivatives

Contact Info

Product

Resources

About