volume 5, issue 3, P550-556 2014
DOI: 10.5155/eurjchem.5.3.550-556.1059
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Abstract: KEYWORDSIn the present manuscript, we report synthesis of new 3 and 5 substituted 2-imino thiazolidine-4-ones by three step synthetic protocols from 3-trifluormethyl aniline or 2-amino heterocycle. The compounds were evaluated for in vitro activities against Mycobacterium tuberculosis (MTB) in presence and absence of efflux pump inhibitor, cytotoxicity against RAW 264.7 cells. Among the thirty six compounds, 2-imino-3-(5-nitrothiazol-2-yl)-5-(3,4,5trimethoxybenzylidene)thiazolidin-4-one (5g) was found to be t…

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