Synthesis and antiproliferative activity of benzophenone tagged pyridine analogues towards activation of caspase activated DNase mediated nuclear fragmentation in Dalton’s lymphoma

Al‐Ghorbani, Mohammed; Thirusangu, Prabhu; Gurupadaswamy, H. D.; Girish, V.; Neralagundi, H.G. Shamanth; Prabhakar, B.T.; Khanum, Shaukath Ara

doi:10.1016/j.bioorg.2016.02.001

Cited by 31 publications

(11 citation statements)

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“…Among the various classes of azoles, the imidazole moiety with two nitrogen atoms is extremely common in nature and forms the core of many biomolecules (Chopra & Sahu, 2019) and synthetic drugs (Pozharskii et al, 2011). Furthermore, pyridine and its derivatives are present in many important compounds, including pharmaceuticals, vitamins (Al-Ghorbani et al, 2016) and drugs, acting as antimicrobial, antiviral, antioxidants, antidiabetic, anti-malarial, anti-inflammatory or antiamoebic agents, as well as psychopharmacological antagonists (Altaf et al, 2015). Hence, the combination of pyridine and imidazole derivatives has been proven to result in highly active agents in ISSN 2056-9890 diverse biological fields that include anticancer (Kamal et al, 2014;Mantu et al, 2016), anti-HIV (Bode et al, 2011), antibacterial (Rival et al, 1992) and anti-inflammatory (Rupert et al, 2003) properties.…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure, DFT calculation, Hirshfeld surface analysis and energy framework study of 6-bromo-2-(4-bromophenyl)imidazo[1,2-a]pyridine

Khamees¹,

Chaluvaiah²,

El-Khatatneh³

et al. 2019

Acta Crystallogr E Cryst Commun

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Section: Chemical Contextmentioning

confidence: 99%

Crystal structure, DFT calculation, Hirshfeld surface analysis and energy framework study of 6-bromo-2-(4-bromophenyl)imidazo[1,2-a]pyridine

Khamees¹,

Chaluvaiah²,

El-Khatatneh³

et al. 2019

Acta Crystallogr E Cryst Commun

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“…One of the characteristics of apoptosis is caspase cascade signaling activation including caspase 3, caspase 8, or caspase 9 (Savitskaya and Onishchenko, 2015). Activated caspases cleave important structural proteins and cause the destruction of organelles, such as the Golgi (Chiu et al, 2002), mitochondria (Yu et al, 2014), and nucleus (Al-Ghorbani et al, 2016). The currently known Golgi structural proteins that can be cleaved by activated caspases are described in the following subsections.…”

Section: Activated Caspases Cleave Golgi Structural Proteinsmentioning

confidence: 99%

The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases

Liu

Deng

et al. 2020

Front. Cell Dev. Biol.

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Increasing evidence shows that, in addition to the classical function of protein processing and transport, the Golgi apparatus (GA) is also involved in apoptosis, one of the most common forms of cell death. The structure and the function of the GA is damaged during apoptosis. However, the specific effect of the GA on the apoptosis process is unclear; it may be involved in initiating or promoting apoptosis, or it may inhibit apoptosis. Golgi-related apoptosis is associated with a variety of neurological diseases including glioma, Alzheimer's disease (AD), Parkinson's disease (PD), and ischemic stroke. This review summarizes the changes and the possible mechanisms of Golgi structure and function during apoptosis. In addition, we also explore the possible mechanisms by which the GA regulates apoptosis and summarize the potential relationship between the Golgi and certain neurological diseases from the perspective of apoptosis. Elucidation of the interaction between the GA and apoptosis broadens our understanding of the pathological mechanisms of neurological diseases and provides new research directions for the treatment of these diseases. Therefore, we propose that the GA may be a potential therapeutic target for apoptosis-related neurological diseases.

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“…Nemorosone has anti-proliferative activity by targeting Akt/PKB against LAN-1 parental cell line [ 18 ] and cytotoxic activity against HeLa, eHep-2, PC-3 and U251 cancer cells [ 19 , 20 ]. Besides, a series of synthesized benzophenones exhibited anti-proliferative activity against DLA cells [ 21 ]. In our studies, some of them exhibited good XOD inhibitory activities, such as those substituted by hydroxyls [ 22 ] and thiazolidinone groups [ 23 ], making them promising as potential anti-hyperuricemic agents, although their in vivo anti-hyperuricemic effects were not reported.…”

Section: Introductionmentioning

confidence: 99%

Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD

Yong

et al. 2018

Molecules

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Conventionally, benzophenone-type molecules are beneficial for alleviating the UV exposure of humans. More importantly, various compounds with this skeleton have demonstrated various biological activities. In this paper, we report the anti-hyperuricemic effect of the benzophenone compound 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (HMS). Preliminarily, its molecular docking score and xanthine oxidase (XOD) inhibition suggested a good anti-hyperuricemic effect. Then, its anti-hyperuricemic effect, primary mechanisms and general toxicity were examined on a hyperuricemic mouse model which was established using potassium oxonate and hypoxanthine together. HMS demonstrated a remarkable anti- hyperuricemic effect which was near to that of the control drugs, showing promising perspective. General toxicity was assessed and it showed no negative effects on body weight growth and kidney function. Moreover, anti-inflammatory action was observed for HMS via spleen and thymus changes. Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9).

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Synthesis and antiproliferative activity of benzophenone tagged pyridine analogues towards activation of caspase activated DNase mediated nuclear fragmentation in Dalton’s lymphoma

Cited by 31 publications

References 32 publications

Crystal structure, DFT calculation, Hirshfeld surface analysis and energy framework study of 6-bromo-2-(4-bromophenyl)imidazo[1,2-a]pyridine

Crystal structure, DFT calculation, Hirshfeld surface analysis and energy framework study of 6-bromo-2-(4-bromophenyl)imidazo[1,2-a]pyridine

The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases

Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD

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