Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones

Sunitha, V.; Kumar, A. Kishore; Mahesh, M.; Shankaraiah, P.; Pochampally, Jalapathi; Lincoln, Ch. Abraham

doi:10.1134/s1070363218090232

Cited by 8 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osmaniye and co-workers reported the synthesis of imidazole-based chalcones that incorporate pharmacophores through a Claisen−Schmidt condensation reaction from imidazole-acetophenone with the corresponding 4-substituted benzaldehyde derivatives. 55 The antifungal activity of the synthesized compounds was evaluated for anticandidal activity against Candida albicans (ATCC 24433), Candida krusei (ATCC 6258), Candida parapsilosis (ATCC 22019), and Candida glabrata (ATCC 90030) in the presence of reference agents ketoconazole and fluconazole. Compound 148 exhibited similar antifungal activity with the reference drug ketoconazole against all Candida species and was evaluated as the most active derivative in the series.…”

Section: Biological Activities Of Chalcones Bearing An N-heterocyclic...mentioning

confidence: 99%

“…Compound 148 exhibited similar antifungal activity with the reference drug ketoconazole against all Candida species and was evaluated as the most active derivative in the series. In a similar fashion, Sunitha and co-workers reported the synthesis of series of bisisoxazole derivatives blended with chalcone derivatives . Antifungal activities of all synthesized derivatives were tested against Microsporum canis, Microsporum gypseum, and Epidermophyton floccosum in 75 and 100 μg/mL concentrations with the reference drug nystatin.…”

Section: Biological Activities Of Chalcones Bearing An N-heterocyclic...mentioning

confidence: 99%

“…In a similar fashion, Sunitha and co-workers reported the synthesis of series of bisisoxazole derivatives blended with chalcone derivatives. 56 Antifungal activities of all synthesized derivatives were tested against Microsporum canis , Microsporum gypseum , and Epidermophyton floccosum in 75 and 100 μg/mL concentrations with the reference drug nystatin. Compound 149 , 150 , and 151 display the highest antifungal activity and also show potent antibacterial activity ( Figure 5 ).…”

Section: Biological Activities Of Chalcones Bearing An N ...mentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing N-Heterocyclic Scaffolds: A Review

2023

View full text Add to dashboard Cite

The incorporation of heterocyclic moieties into the standard chemical structure with a biologically active scaffold has become of crucial practice for the construction of pharmacologically potent candidates in the drug arena. Currently, numerous kinds of chalcones and their derivatives have been synthesized using the incorporation of heterocyclic scaffolds, especially chalcones bearing heterocyclic moieties that display improved efficiency and potential for drug production in pharmaceutical sectors. The current Review focuses on recent advances in the synthetic approaches and pharmacological activities such as antibacterial, antifungal, antitubercular, antioxidant, antimalarial, anticancer, antiinflammatory, antigiardial, and antifilarial activities of chalcone derivatives incorporating N-heterocyclic moieties at either the A-ring or B-ring.

show abstract

Section: Biological Activities Of Chalcones Bearing An N-heterocyclic...mentioning

confidence: 99%

Section: Biological Activities Of Chalcones Bearing An N-heterocyclic...mentioning

confidence: 99%

Section: Biological Activities Of Chalcones Bearing An N ...mentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing N-Heterocyclic Scaffolds: A Review

2023

View full text Add to dashboard Cite

show abstract

“…[13][14][15][16] Chalcone being a biologically active compound itself reported many properties like antibacterial 17] , antioxidant [18] , antimycobacterial [19] , antitumor [20] , antituberculosis [14] , and cytotoxicity [21] . Apart from this, they are also used to synthesise many heterocycles such as benzodiazepines [22] , pyrazolines [23,24] , isoxazoles [25] etc. The chapter discusses the biological activities of benzodiazepines which are synthesised using chalcones as starting materials.…”

Section: Introductionmentioning

confidence: 99%

A Study on Biologically Active Chalcone Based Benzodiazepines

2022

View full text Add to dashboard Cite

Heterocycles that include nitrogen are now indispensable to humanity. The majority of the major pharmaceuticals on the market are composed of heterocycles that include nitrogen. One such substance is benzodiazepine, which was shown to have potential as an anti-anxiety medication in 1955. A novel class of chalcone-based benzodiazepines continues to receive the most attention because of their enhanced pharmacological, medicinal, and biological actions. The present study covers the chemistry of some important biologically active chalcone-based benzodiazepines.

show abstract

“…Antimicrobial agents of both synthetic and natural origin can provide the means to treat infections caused by microorganisms thus saving millions of lives. Diarylpropenones commonly called as chalcones has biological activities against microbial [4][5][6][7][8][9][10][11][12] and tubercular infections [13], oxidative stress 14], cancer, fungal infections, liver diseases, bronchitis [15][16][17], antimalarial [18] etc.,. Chalcone is chemically 1,3-diaryl-2-propen-1-one in which the two aromatic rings are joined by a three-carbon ,β-unsaturated carbonyl system, representing a class of flavonoids that occurs naturally in fruits and vegetables.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and screening of novel lipophilic diarylpropeones as prospective antitubercular, antibacterial and antifungal agents

2019

Biointerface Res Appl Chem

View full text Add to dashboard Cite

Infectious diseases including bacterial, fungal and tuberculosis are responsible for the suffering of humans worldwide. Based on this observation we predetermined to prepare and five novel lipophilic diarylpropenones (Chalcones) (3a-3e) against tubercular, bacterial and fungal strains. The compounds were prepared by base the catalyzed condensation of 2,4,6-trimethyl acetophenone with substituted aromatic aldehydes, purified by recrystallization and characterized by elemental analysis and IR, 1H NMR, and Mass spectroscopic techniques. Further, the compounds were biologically screened for their antitubercular, antibacterial, and antifungal actions. Results of these activities revealed that the compounds possess potential antifungal and antitubercular activities and poor antibacterial activity. The greater activities against tubercular and fungal strains may be due to the lipophilicity rendered by the three magic methyl groups and halogen atoms. The compounds showed no cytotoxicity against the normal human cell line L02. These compounds may act as new scaffolds for the design and development of new molecules against tubercular and fungal infections. Advanced studies need to be carried out in order to determine their potency in vivo.

show abstract

Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones

Cited by 8 publications

References 20 publications

Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing N-Heterocyclic Scaffolds: A Review

Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing N-Heterocyclic Scaffolds: A Review

A Study on Biologically Active Chalcone Based Benzodiazepines

Synthesis and screening of novel lipophilic diarylpropeones as prospective antitubercular, antibacterial and antifungal agents

Contact Info

Product

Resources

About