Synthesis and antimicrobial evaluation of new thiazolyl-1,2,3-triazolyl-alcohol derivatives

Synthesis, antimicrobial and ergosterol biosynthesis inhibition activity of clubbed 1,1′-biphenyl-pyrazole derivatives

“…The synthesized 1,1 0 -biphenylpyrazole derivatives were evaluated for antimicrobial activity against the Gram-negative bacteria E. coli, P. mirabilis, Grampositive bacteria B. subtilis, S. albus, and fungal strains C. albicans and A. niger using the well diffusion method. [46][47][48] The antibacterial drug Streptomycin and antifungal drugs Fluconazole and Ravuconazole were used as positive controls. All the test solutions were prepared in DMSO at 500 mg mL À1 concentrations and the wells were filled with 80 mL (40 mg) of the samples.…”

“…The in vitro antibacterial screening of the synthesized derivatives was done by the well diffusion method [46][47][48] against the standard strains of Gram-negative bacteria Escherichia coli (NCIM 2574), Proteus mirabilis (NCIM 2388) and Grampositive bacteria Bacillus subtilis (NCIM 2063) and Staphylococcus albus (NCIM 2178). All the strains were procured from the National Collection of Industrial Microorganisms (NCIM) NCL, Pune, India.…”

A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)

“…As it is shown in Figure 59, a series of novel derivatives of 1-(4-methyl-2-aryl-1,3-thiazole-5yl)-2-(4-aryl-1,2,3-triazol-1-yl) ethanol were synthesized and their antifungal properties screened in vitro against Candida albicans, Aspergillus niger, Rhodotorula glutinis, and Penicillium chrysogenum. Most of the compounds have moderate-to-good antifungal activity against A. niger in comparison to the standard medicine Ravuconazole [124]. otla et al [125] synthesized a new series of Benzo[b] thiophene triazoles with high yields from various azides with propargyl derivatives of benzothiophene, and most of them displayed significant antifungal activity against the fungi tested (Sclerotium rolfsii and Aspergillus niger) (Figure 60).…”

Synthesis and biological evaluation of novel 4‐(6‐substituted quinolin‐4‐yl)‐N‐aryl thiazol‐2‐amine derivatives as potential antimicrobial agents

“…Quinoline derivatives displayed vital pharmacological activities such as antimalarial [9,10], antimicrobial [11,12], antifungal [13,14], antitubercular [15,16], anticancer [17,18], antiviral [19,20], antiinflammatory and COX inhibitors [21,22], carbonic anhydrase inhibitors [23], antileishmanial [24], PIM inhibitors [25], anticonvulsant, and antihypertensive [26] activities. Thiazole is the important scaffold of several bioactive natural products [27,28] and reported broad spectrum of biological activity such as antibacterial [29,30], inflammatory [31], antifungal [32,33], antitubercular [34,35], antimalarial [36], anticancer [37], antiviral [38], and CNS active agents [39]. The quinoline tethered azoles are the significant architecture that has received attention due to their potential biological activity [40–43].…”