Synthesis and Antimicrobial Activity of Some New Substituted Quinoxalines

El‐Atawy, Mohamed A.; Hamed, Ezzat A.; Alhadi, Mahjoba; Omar, Alaa Z.

doi:10.3390/molecules24224198

Cited by 31 publications

(16 citation statements)

References 38 publications

(37 reference statements)

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“…The symmetrically disubstituted quinoxalines 2, 3, 4, and 5 displayed the most significant antibacterial activity, while compounds 6a, 6b, and the pentacyclic compound 10 showed considerable antifungal activity. Furthermore, compounds 3f, 6b showed broad antimicrobial spectrum against most of the tested strains 24 .…”

Section: Quinoxalines Derivativesmentioning

confidence: 96%

A review of compounds derivatives with antimicrobial activities

Thangabalan¹,

Mahesh²

2023

World J. Bio. Pharm. Health Sci.

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Antimicrobial resistance represents a serious threat to human health across the globe. The cost of bringing a new antibiotic from discovery to market is high and return on investment is low. Furthermore, the development of new antibiotics has slowed dramatically since the 1950s’ golden age of discovery. Medicinal compounds synthesis produce a variety of bioactive compounds that could be used to build a new way for the future discovery pipeline. While many studies have focused on specific aspects of synthetic compounds with antibacterial properties, a comprehensive review of the antibacterial potential of compounds has never before been attempted. This review aims to evaluate reports on some derivatives with significant antimicrobial activities.

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Section: Quinoxalines Derivativesmentioning

confidence: 96%

A review of compounds derivatives with antimicrobial activities

Thangabalan¹,

Mahesh²

2023

World J. Bio. Pharm. Health Sci.

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“…All the synthesized compounds 2-10 were tested for their antimicrobial activity against S. aureus and B. subtilis as species of gram-positive bacteria and E. Coli and P. vulgaris as species of gram-negative bacteria. They were also tested against fungi like C. albicans and A. flavus using the Agar Well Diffusion technique [59,60]. Gentamycin and Ketoconazole were used as antibacterial and antifungal reference drugs, respectively.…”

Section: Antimicrobial Studiesmentioning

confidence: 99%

Synthesis and Antimicrobial Activity Screening of Piperazines Bearing N,N′-Bis(1,3,4-thiadiazole) Moiety as Probable Enoyl-ACP Reductase Inhibitors

et al. 2022

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A new N,N′-disubstituted piperazine conjugated with 1,3,4-thiadiazole and 1,2,4-triazole was prepared and the chemical structures were identified by IR, NMR and elemental analysis. All the prepared compounds were tested for their antimicrobial activity. The antimicrobial results indicated that the tested compounds showed significant antibacterial activity against gram-negative strains, especially E. coli, relative to gram-positive bacteria. Docking analysis was performed to support the biological results; binding modes with the active site of enoyl reductase amino acids from E. coli showed very good scores, ranging from −6.1090 to −9.6184 kcal/mol. Correlation analysis was performed for the inhibition zone (nm) and the docking score.

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“…It has various activities demonstrated by its presence in biologically important antibiotics such as levomycin, actinoleutin, and echinomycin, which are useful in several transplantable tumours. It possesses industrial applications such as dyes, agricultural and medicinal chemistry also wide spectrum of biological activities like anticancer, anti-inflammatory, antiviral 20 , antidiabetic, antidepressant, anthelmintic, antituberculosis, antimicrobial 19 and antiprotozoal 17 .…”

Section: Fig 1: Quinoxaline-containing Antibioticsmentioning

confidence: 99%

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2022

IJPSR

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Substituted quinoxaline has received considerable attention during the last few years as they are endowed with various biological activities and have a wide range of therapeutic properties. Piperazine has proven its worth in numerous clinically active drugs broader areas of therapeutic index. Hence, biologically important quinoxaline derivatives containing a piperazine moiety and Schiff base scaffolds were prepared. The structures of the synthesized compounds were characterised by elemental analysis, IR, NMR, and Mass spectra. All the prepared derivatives were screened for antibacterial and antifungal activity by disc diffusion method using nutrient agar media against Bacillus subtilis, Bacillus pumilus, Escherichia coli and Pseudomonas aeruginosa, & potato dextrose agar medium for activity against Aspergillus niger and Candida albicans using ciprofloxacin as a standard for antibacterial and clotrimazole as a standard for antifungal activity respectively. Fluoro and trimethoxy-containing derivatives have shown promising activity against gram-ve bacteria P. aeruginosa. Some compounds have shown moderate antifungal and antibacterial activity. INTRODUCTION:Quinoxaline derivatives are an important class of heterocyclic compounds, formed by replacing carbon atoms in naphthalene ring with an N atom. Quinoxaline consists of two rings, one aromatic benzene ring, and another heterocyclic aromatic pyrazine ring because of which this is also called benzopyrazine. It is recognized as a bioisoster of quinoline, naphthalene and benzothiophene. Quinoxaline has occupied an enormous focus against biologically important broad-spectrum bacteria, fungi, viruses, leishmania, tuberculosis, malaria, cancer, depression, and neurological activities.

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Synthesis and Antimicrobial Activity of Some New Substituted Quinoxalines

Cited by 31 publications

References 38 publications

A review of compounds derivatives with antimicrobial activities

A review of compounds derivatives with antimicrobial activities

Synthesis and Antimicrobial Activity Screening of Piperazines Bearing N,N′-Bis(1,3,4-thiadiazole) Moiety as Probable Enoyl-ACP Reductase Inhibitors

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