Synthesis and Antimicrobial Activity of Bis-1,2,3-triazole Based Chalcones

Sunitha, V.; Kumar, A. Kishore; Pochampally, Jalapathi; Lincoln, Ch. Abraham

doi:10.1134/s1070363220010247

Cited by 9 publications

(5 citation statements)

References 4 publications

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“…Chalcone-triazole derivatives not only possess anticancer activity 60 , 61 , 101 , 102 and anti-inflammatory activity 114 , but also they exhibit antibacterial activity 125–127 . The newly synthesised bis-1,2,3-triazole based chalcones were tested for their antibacterial activity 125 . The compounds demonstrated significant inhibition of tested gram positive and gram negative strains compared to the standard drug Gentamicin sulphate.…”

Section: Biological Activitiesmentioning

confidence: 99%

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Application of triazoles in the structural modification of natural products

Guo

Zheng-ai

Shen

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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Nature products have been extensively used in the discovery and development of new drugs, as the most important source of drugs. The triazole ring is one of main pharmacophore of the nitrogen-containing heterocycles. Thus, a new class of triazole-containing natural product conjugates has been synthesised. These compounds reportedly exert anticancer, anti-inflammatory, antimicrobial, antiparasitic, antiviral, antioxidant, anti-Alzheimer, and enzyme inhibitory effects. This review summarises the research progress of triazole-containing natural product derivatives involved in medicinal chemistry in the past six years. This review provides insights and perspectives that will help scientists in the fields of organic synthesis, medicinal chemistry, phytochemistry, and pharmacology.

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Section: Biological Activitiesmentioning

confidence: 99%

“…Chalcone-triazole derivatives not only possess anticancer activity 60 , 61 , 101 , 102 , anti-inflammatory activity 114 , antibacterial activity 125–127 , and antibacterial activity 134 , but also they exhibit antimalarial activity 143 , 144 . Kant et al.…”

Section: Biological Activitiesmentioning

confidence: 99%

Application of triazoles in the structural modification of natural products

Guo

Zheng-ai

Shen

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Sunitha et al (2020) synthesized 12 chalcone derivatives ( 54a – 54l , Figure 19 ) and screened their antimicrobial activity [ 94 ]. The CuAAC reaction was performed in the O -propargylated acetophenone with excellent yields.…”

Section: 123-triazole-linked Flavonoid Hybrids With Antimicrobial Activitymentioning

confidence: 99%

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

et al. 2021

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As a result of the biological activities of natural flavonoids, several synthetic strategies aiming to obtain analogues with improved potency and/or pharmacokinetic profile have been developed. Since the triazole ring has been associated with several biological activities and metabolic stability, hybridization with a 1,2,3-triazole ring has been increasingly reported over the last years. The feasible synthesis through copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) has allowed the accomplishment of several hybrids. Since 2017, almost 700 flavonoid hybrids conjugated with 1,2,3-triazole, including chalcones, flavones, flavanones and flavonols, among others, with antitumor, antimicrobial, antidiabetic, neuroprotective, anti-inflammatory, antioxidant, and antifouling activity have been reported. This review compiles the biological activities recently described for these hybrids, highlighting the mechanism of action and structure–activity relationship (SAR) studies.

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“…Jalapathi et al reported that bis-triazole-chalcone hybrid H10 could exert comparable antibacterial activity to the reference drug gentamicin sulphate against several Gram-positive ( Micrococcus luteus, methicillin-resistant Staphylococcus aureus, Bacillus subtilis, and Bacillus cereus ) and Gram-negative ( Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Proteus vulgaris ) bacterial strains at concentrations of 75 and 100 μ /ml ( Sunitha et al, 2020 ).…”

Section: Click Chemistry-based Modification Of Phenylpropanoidsmentioning

confidence: 99%

Click Chemistry in Natural Product Modification

Zhang

Zhao

et al. 2021

Front. Chem.

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Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now. It enables the ready synthesis of diverse sets of natural product derivatives either for the optimization of their drawbacks or for the construction of natural product-like drug screening libraries. This paper showcases the state-of-the-art development of click chemistry in natural product modification and summarizes the pharmacological activities of the active derivatives as well as the mechanism of action. The aim of this paper is to gain a deep understanding of the fruitful achievements and to provide perspectives, trends, and directions regarding further research in natural product medicinal chemistry.

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Synthesis and Antimicrobial Activity of Bis-1,2,3-triazole Based Chalcones

Cited by 9 publications

References 4 publications

Application of triazoles in the structural modification of natural products

Application of triazoles in the structural modification of natural products

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

Click Chemistry in Natural Product Modification

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