Synthesis and Antimicrobial Activity of Thioxopyrimidines and Related Derivatives

Synthesis of Pyrazolo‐[4́,3́:5,6]pyrido[2,3‐d]pyrimidine‐diones Catalyzed by a Nano‐sized Surface‐Grafted Neodymium Complex of the Tungstosilicate via Multicomponent Reaction

“…In the midst of polyfunctionalized heterocycles, pyridopyrimidines are the most favored structures for developing drug discovery due to providing a wide range of pharmacological activities, such as anti‐cancer, antimicrobial, anti‐HIV, anti‐inflammatory, anti‐malarial and anti‐tubercular . Moreover, such compounds are valuable in chemotherapy research due to their potential properties as inhibitors of 5‐phosphoribosyl‐1‐pyrophosphate synthetase, dihydrofolate reductase, and specifically, tyrosine kinase as an important enzyme in regulating cell division .…”

An efficient three-component, one-pot synthesis of 2-alkylthio-4-amino-5-cyano-6-aryl(alkyl)pyrimidines in water

“…1) [20][21][22]. To the best of our knowledge, there are mainly two methods for the synthesis of 2-alkylthio-4-amino-5-cyano-6aryl(alkyl)pyrimidines [23][24][25][26][27][28][29], as shown in Scheme 1. Both require at least 2-3 synthetic steps using organic solvents under heating, which requires a tedious work-up, there is a limitation in reactant/substrates, and the method offers unsatisfactory yields.…”

Synthesis of novel pyrimidine and fused pyrimidine derivatives

“…This prompted us to reinvestigate the proclivity of compound 2 with electrophilic reagents such as, pentane-2,4-dione, acetic anhydride, furoyl chloride, phthalic anhydride, ethyl chloroformate, carbon disulphide, 2-(3,4-dimethoxybenzylidene) malononitrile, p-nitrobenzaldehyde, phenyl isothiocyanate and diethyl oxalate with the aim of preparing new pyrimidine derivatives which might have chemotherapeutic and biological evaluation. Thus, treatment of the 2-hydrazino derivative 2 with pentane-2,4-dione in refluxing ethanol afforded 4-amino-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile (3) [6].…”

“…The recent wide applications of pyrimidine derivatives as anti-tumor [1], anti-HIV-1 [2], analgesic [3], anti-depressive [4], anti-convulsant [5], anti-microbial [6], herbicides [7,8], antiinflammatory and antioxidant [3,9], beside their uses as a precursors in the synthesis of fused ring compounds like, triazolopyrimidines as antibacterial agents [10], fungicidal [11], and anti-tumor agents [12], imidazopyrimidines as antimycobacterial [13] and pyridopyrimidines as antibacterial agents [14] make them worthy to be synthesized and evaluated as drugs. We report here synthesis of pyrimidine and fused pyrimidines by developed, simple, convenient and efficient procedure.…”